PLGA nanocomposites loaded with verteporfin and gold nanoparticles for enhanced photodynamic therapy of cancer cells

Deng, W; Kautzka, Z; Chen, W; Goldys, EM

PLGA nanocomposites loaded with verteporfin and gold nanoparticles for enhanced photodynamic therapy of cancer cells

Deng, W

Kautzka, Z Chen, W Goldys, EM

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Publisher:: ROYAL SOC CHEMISTRY
Publication Type:: Journal Article
Citation:: RSC Advances, 2016, 6, (113), pp. 112393-112402
Issue Date:: 2016-01-01

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Field	Value	Language
dc.contributor.author	Deng, W https://orcid.org/0000-0002-9413-0978
dc.contributor.author	Kautzka, Z
dc.contributor.author	Chen, W
dc.contributor.author	Goldys, EM
dc.date.accessioned	2022-08-15T21:54:36Z
dc.date.available	2022-08-15T21:54:36Z
dc.date.issued	2016-01-01
dc.identifier.citation	RSC Advances, 2016, 6, (113), pp. 112393-112402
dc.identifier.issn	2046-2069
dc.identifier.issn	2046-2069
dc.identifier.uri	http://hdl.handle.net/10453/160264
dc.description.abstract	In this paper, PLGA nanocomposites were developed by incorporating a photosensitizer, verteporfin and gold nanoparticles into the polymeric matrix and utilised for enhanced photodynamic therapy of cancer cells. Both enhanced fluorescence and 1O2 generation from verteporfin were observed in this new formulation under both 425 nm LED and 405 nm laser illumination. A maximum enhancement factor of 2.5 for fluorescence and 1.84 for 1O2 generation was obtained when the molar ratio of gold : VP was 5 : 1 and excited at 425 nm, compared with PLGA doped with verteporfin alone. The experiment results could be explained by the local electric field enhancement of gold nanoparticles. Furthermore, improved therapeutic efficacy in human pancreatic cancer cells, PANC-1, was also demonstrated by using this new formulation following light exposure, indicating the utility of these nanocomposites for enhanced photodynamic therapy.
dc.language	English
dc.publisher	ROYAL SOC CHEMISTRY
dc.relation	http://purl.org/au-research/grants/arc/DE130100894
dc.relation	http://purl.org/au-research/grants/arc/CE140100003
dc.relation.ispartof	RSC Advances
dc.relation.isbasedon	10.1039/c6ra21997g
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	03 Chemical Sciences
dc.title	PLGA nanocomposites loaded with verteporfin and gold nanoparticles for enhanced photodynamic therapy of cancer cells
dc.type	Journal Article
utslib.citation.volume	6
utslib.for	03 Chemical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2022-08-15T21:54:34Z
pubs.issue	113
pubs.publication-status	Published
pubs.volume	6
utslib.citation.issue	113

Abstract:

In this paper, PLGA nanocomposites were developed by incorporating a photosensitizer, verteporfin and gold nanoparticles into the polymeric matrix and utilised for enhanced photodynamic therapy of cancer cells. Both enhanced fluorescence and 1O2 generation from verteporfin were observed in this new formulation under both 425 nm LED and 405 nm laser illumination. A maximum enhancement factor of 2.5 for fluorescence and 1.84 for 1O2 generation was obtained when the molar ratio of gold : VP was 5 : 1 and excited at 425 nm, compared with PLGA doped with verteporfin alone. The experiment results could be explained by the local electric field enhancement of gold nanoparticles. Furthermore, improved therapeutic efficacy in human pancreatic cancer cells, PANC-1, was also demonstrated by using this new formulation following light exposure, indicating the utility of these nanocomposites for enhanced photodynamic therapy.

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http://hdl.handle.net/10453/160264