Modulating the cellular uptake of platinum drugs with glycopolymers
- Publisher:
- ROYAL SOC CHEMISTRY
- Publication Type:
- Journal Article
- Citation:
- Polym. Chem., 2016, 7, (5), pp. 1031-1036
- Issue Date:
- 2016
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c5py01579k.pdf | Published version | 1.16 MB |
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The therapeutic potency of platinum-based anticancer drugs can be substantially improved through the use of polymeric nanocarrier systems to target cancer cells efficiently. We synthesized a series of glyco-block copolymers with three different sugars able to self-assemble into nanoparticles when conjugated with 1,2-diamino-cyclopentane platinum(ii) (DACP-Pt). The polymers are based on (2-(d-glucosyloxy)ethyl methacrylate (glucose; GlcMA), 2-(d-galactosyloxy)ethyl methacrylate (galactose; GalMA), 1-O-methacryloyl-β-d-fructopyranose (fructose; FrucMA1), and 3-O-methacryloyl-β-d-fructopyranose (fructose; FrucMA3)). They are all readily taken up intracellularly by the breast cancer cell lines MCF-7 and MDA-MB-231 and the ovarian cancer cell line A2780. All cell lines expressed a high preference for the fructose coated nanoparticles. The nanocarriers were themselves nontoxic, but exhibited high cytotoxicity and increased efficacy when conjugated with the DACP-Pt drug.
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