Synthesis of microcapsules using inverse emulsion periphery RAFT polymerization via SPG membrane emulsification

Ishizuka, F; Kuchel, RP; Lu, H; Stenzel, MH; Zetterlund, PB

Synthesis of microcapsules using inverse emulsion periphery RAFT polymerization via SPG membrane emulsification

Ishizuka, F Kuchel, RP Lu, H

Stenzel, MH Zetterlund, PB

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Publisher:: ROYAL SOC CHEMISTRY
Publication Type:: Journal Article
Citation:: Polymer Chemistry, 2016, 7, (46), pp. 7047-7051
Issue Date:: 2016

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Field	Value	Language
dc.contributor.author	Ishizuka, F
dc.contributor.author	Kuchel, RP
dc.contributor.author	Lu, H https://orcid.org/0000-0001-6932-1900
dc.contributor.author	Stenzel, MH
dc.contributor.author	Zetterlund, PB
dc.date.accessioned	2022-08-21T21:52:31Z
dc.date.available	2022-08-21T21:52:31Z
dc.date.issued	2016
dc.identifier.citation	Polymer Chemistry, 2016, 7, (46), pp. 7047-7051
dc.identifier.issn	1759-9954
dc.identifier.issn	1759-9962
dc.identifier.uri	http://hdl.handle.net/10453/160622
dc.description.abstract	Hollow particles have the potential for a broad range of applications, but most specifically drug delivery. However, their synthesis can be tedious, requiring techniques such as high energy input or a sacrificial template. Furthermore, loading the final capsules with drugs, catalysts or any other compound is often associated with a low loading efficiency. In this study, we have explored the use of "Shirasu Porous Glass (SPG)" membrane emulsification to create a wide size range of water droplets stabilized with an amphiphilic block copolymer. Polymeric capsules were subsequently created via inverse emulsion periphery RAFT polymerization (IEPP). By changing the pore size of the SPG membrane (0.2-3 μm), we have succeeded in controlling the polymeric microcapsule size from submicron to tens of microns. In addition to this, the process allowed simultaneous and efficient encapsulation of water-soluble compounds such as proteins.
dc.language	English
dc.publisher	ROYAL SOC CHEMISTRY
dc.relation.ispartof	Polymer Chemistry
dc.relation.isbasedon	10.1039/c6py01584k
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0307 Theoretical and Computational Chemistry
dc.title	Synthesis of microcapsules using inverse emulsion periphery RAFT polymerization via SPG membrane emulsification
dc.type	Journal Article
utslib.citation.volume	7
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0307 Theoretical and Computational Chemistry
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	in_progress	*
dc.date.updated	2022-08-21T21:52:30Z
pubs.issue	46
pubs.publication-status	Published
pubs.volume	7
utslib.citation.issue	46

Abstract:

Hollow particles have the potential for a broad range of applications, but most specifically drug delivery. However, their synthesis can be tedious, requiring techniques such as high energy input or a sacrificial template. Furthermore, loading the final capsules with drugs, catalysts or any other compound is often associated with a low loading efficiency. In this study, we have explored the use of "Shirasu Porous Glass (SPG)" membrane emulsification to create a wide size range of water droplets stabilized with an amphiphilic block copolymer. Polymeric capsules were subsequently created via inverse emulsion periphery RAFT polymerization (IEPP). By changing the pore size of the SPG membrane (0.2-3 μm), we have succeeded in controlling the polymeric microcapsule size from submicron to tens of microns. In addition to this, the process allowed simultaneous and efficient encapsulation of water-soluble compounds such as proteins.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/160622