Profluorescent PPV-Based Micellar System as a Versatile Probe for Bioimaging and Drug Delivery

Zaquen, N; Lu, HX; Chang, T; Mamdooh, R; Lutsen, L; Vanderzande, D; Stenzel, M; Junkers, T

Profluorescent PPV-Based Micellar System as a Versatile Probe for Bioimaging and Drug Delivery

Zaquen, N Lu, HX Chang, T Mamdooh, R Lutsen, L Vanderzande, D Stenzel, M Junkers, T

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Publisher:: AMER CHEMICAL SOC
Publication Type:: Journal Article
Citation:: Biomacromolecules, 2016, 17, (12), pp. 4086-4094
Issue Date:: 2016

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Field	Value	Language
dc.contributor.author	Zaquen, N
dc.contributor.author	Lu, HX
dc.contributor.author	Chang, T
dc.contributor.author	Mamdooh, R
dc.contributor.author	Lutsen, L
dc.contributor.author	Vanderzande, D
dc.contributor.author	Stenzel, M
dc.contributor.author	Junkers, T
dc.date.accessioned	2022-08-21T22:10:22Z
dc.date.available	2022-08-21T22:10:22Z
dc.date.issued	2016
dc.identifier.citation	Biomacromolecules, 2016, 17, (12), pp. 4086-4094
dc.identifier.issn	1525-7797
dc.identifier.issn	1526-4602
dc.identifier.uri	http://hdl.handle.net/10453/160628
dc.description.abstract	Although micelles are commonly used for drug delivery purposes, their long-term fate is often unknown due to photobleaching of the fluorescent labels or the use of toxic materials. Here, we present a metal-free, nontoxic, nonbleaching, fluorescent micelle that can address these shortcomings. A simple, yet versatile, profluorescent micellar system, built from amphiphilic poly(p-phenylenevinylene) (PPV) block copolymers, for use in drug delivery applications is introduced. Polymer micelles made from PPV show excellent stability for up to 1 year and are successfully loaded with anticancer drugs (curcumin or doxorubicin) without requiring introduction of physical or chemical cross-links. The micelles are taken up efficiently by the cells, which triggers disassembly, releasing the encapsulated material. Disassembly of the micelles and drug release is conveniently monitored as fluorescence of the single polymer chains appear, which enables not only to monitor the release of the payload, but in principle also the fate of the polymer over longer periods of time.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	AMER CHEMICAL SOC
dc.relation.ispartof	Biomacromolecules
dc.relation.isbasedon	10.1021/acs.biomac.6b01653
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	03 Chemical Sciences, 06 Biological Sciences, 09 Engineering
dc.subject.classification	Polymers
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Cell Survival
dc.subject.mesh	Curcumin
dc.subject.mesh	Doxorubicin
dc.subject.mesh	Drug Carriers
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Fluorescent Dyes
dc.subject.mesh	Humans
dc.subject.mesh	Micelles
dc.subject.mesh	Molecular Imaging
dc.subject.mesh	Pancreatic Neoplasms
dc.subject.mesh	Polymers
dc.subject.mesh	Polyvinyls
dc.subject.mesh	Tumor Cells, Cultured
dc.subject.mesh	Tumor Cells, Cultured
dc.subject.mesh	Humans
dc.subject.mesh	Pancreatic Neoplasms
dc.subject.mesh	Curcumin
dc.subject.mesh	Polyvinyls
dc.subject.mesh	Doxorubicin
dc.subject.mesh	Polymers
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Drug Carriers
dc.subject.mesh	Fluorescent Dyes
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Cell Survival
dc.subject.mesh	Micelles
dc.subject.mesh	Molecular Imaging
dc.title	Profluorescent PPV-Based Micellar System as a Versatile Probe for Bioimaging and Drug Delivery
dc.type	Journal Article
utslib.citation.volume	17
utslib.location.activity	United States
utslib.for	03 Chemical Sciences
utslib.for	06 Biological Sciences
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2022-08-21T22:10:18Z
pubs.issue	12
pubs.publication-status	Published
pubs.volume	17
utslib.citation.issue	12

Abstract:

Although micelles are commonly used for drug delivery purposes, their long-term fate is often unknown due to photobleaching of the fluorescent labels or the use of toxic materials. Here, we present a metal-free, nontoxic, nonbleaching, fluorescent micelle that can address these shortcomings. A simple, yet versatile, profluorescent micellar system, built from amphiphilic poly(p-phenylenevinylene) (PPV) block copolymers, for use in drug delivery applications is introduced. Polymer micelles made from PPV show excellent stability for up to 1 year and are successfully loaded with anticancer drugs (curcumin or doxorubicin) without requiring introduction of physical or chemical cross-links. The micelles are taken up efficiently by the cells, which triggers disassembly, releasing the encapsulated material. Disassembly of the micelles and drug release is conveniently monitored as fluorescence of the single polymer chains appear, which enables not only to monitor the release of the payload, but in principle also the fate of the polymer over longer periods of time.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/160628