Effects of Material-Tissue Interactions on Bone Regeneration Outcomes Using Baghdadite Implants in a Large Animal Model.

Li, JJ; Akey, A; Dunstan, CR; Vielreicher, M; Friedrich, O; Bell, DC; Zreiqat, H

Effects of Material-Tissue Interactions on Bone Regeneration Outcomes Using Baghdadite Implants in a Large Animal Model.

Li, JJ Akey, A Dunstan, CR Vielreicher, M Friedrich, O Bell, DC Zreiqat, H

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Adv Healthc Mater, 2018, 7, (15), pp. e1800218
Issue Date:: 2018-08

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Field	Value	Language
dc.contributor.author	Li, JJ
dc.contributor.author	Akey, A
dc.contributor.author	Dunstan, CR
dc.contributor.author	Vielreicher, M
dc.contributor.author	Friedrich, O
dc.contributor.author	Bell, DC
dc.contributor.author	Zreiqat, H
dc.date.accessioned	2022-09-07T22:02:42Z
dc.date.available	2022-09-07T22:02:42Z
dc.date.issued	2018-08
dc.identifier.citation	Adv Healthc Mater, 2018, 7, (15), pp. e1800218
dc.identifier.issn	2192-2640
dc.identifier.issn	2192-2659
dc.identifier.uri	http://hdl.handle.net/10453/161490
dc.description.abstract	Extensive bone loss due to trauma or disease leads to impaired healing. Current bone grafts and substitutes have major drawbacks that limit their effectiveness for treating large bone defects. A number of bone substitutes in development are undergoing preclinical testing, but few studies specifically investigate the in vivo material-tissue interactions that provide an important indicator to long-term implant safety and efficacy. This study is the first of its kind to specifically investigate in vivo material-tissue interactions at the bone-implant interface. Baghdadite scaffolds implanted in critical-sized segmental defects in sheep tibia for 26 weeks are analyzed by focused ion beam scanning electron microscopy, multiphoton microscopy, and histology. The scaffolds are seen to induce extensive bone formation that directly abut the implant surfaces with no evidence of chronic inflammation or fibrous capsule formation. Bone remodeling is influenced by slow in vivo degradation around and within the implant, causing portions of the implant to be incorporated into the newly formed bone. These findings have important implications for predicting the long-term effects of baghdadite ceramics in promoting defect healing, and support the translation of baghdadite scaffolds as a new generation of bone graft substitutes with improved properties for the repair of large bone defects.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation.ispartof	Adv Healthc Mater
dc.relation.isbasedon	10.1002/adhm.201800218
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0304 Medicinal and Biomolecular Chemistry, 0903 Biomedical Engineering, 1004 Medical Biotechnology
dc.subject.mesh	Animals
dc.subject.mesh	Bone Regeneration
dc.subject.mesh	Bone Remodeling
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Microscopy, Electrochemical, Scanning
dc.subject.mesh	Sheep
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Animals
dc.subject.mesh	Sheep
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Bone Remodeling
dc.subject.mesh	Bone Regeneration
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Microscopy, Electrochemical, Scanning
dc.title	Effects of Material-Tissue Interactions on Bone Regeneration Outcomes Using Baghdadite Implants in a Large Animal Model.
dc.type	Journal Article
utslib.citation.volume	7
utslib.location.activity	Germany
utslib.for	0304 Medicinal and Biomolecular Chemistry
utslib.for	0903 Biomedical Engineering
utslib.for	1004 Medical Biotechnology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2022-09-07T22:02:40Z
pubs.issue	15
pubs.publication-status	Published
pubs.volume	7
utslib.citation.issue	15

Abstract:

Extensive bone loss due to trauma or disease leads to impaired healing. Current bone grafts and substitutes have major drawbacks that limit their effectiveness for treating large bone defects. A number of bone substitutes in development are undergoing preclinical testing, but few studies specifically investigate the in vivo material-tissue interactions that provide an important indicator to long-term implant safety and efficacy. This study is the first of its kind to specifically investigate in vivo material-tissue interactions at the bone-implant interface. Baghdadite scaffolds implanted in critical-sized segmental defects in sheep tibia for 26 weeks are analyzed by focused ion beam scanning electron microscopy, multiphoton microscopy, and histology. The scaffolds are seen to induce extensive bone formation that directly abut the implant surfaces with no evidence of chronic inflammation or fibrous capsule formation. Bone remodeling is influenced by slow in vivo degradation around and within the implant, causing portions of the implant to be incorporated into the newly formed bone. These findings have important implications for predicting the long-term effects of baghdadite ceramics in promoting defect healing, and support the translation of baghdadite scaffolds as a new generation of bone graft substitutes with improved properties for the repair of large bone defects.

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http://hdl.handle.net/10453/161490