Preparation and characterization of electrospun PLGA-SF nanofibers as a potential drug delivery system

Deng, Z; Mu, H; Jiang, L; Xi, W; Xu, X; Zheng, W

Preparation and characterization of electrospun PLGA-SF nanofibers as a potential drug delivery system

Deng, Z Mu, H Jiang, L Xi, W Xu, X

Zheng, W

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Publisher:: ELSEVIER SCIENCE SA
Publication Type:: Journal Article
Citation:: Materials Chemistry and Physics, 2022, 289
Issue Date:: 2022-09-15

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Field	Value	Language
dc.contributor.author	Deng, Z
dc.contributor.author	Mu, H
dc.contributor.author	Jiang, L
dc.contributor.author	Xi, W
dc.contributor.author	Xu, X https://orcid.org/0000-0002-2598-3766
dc.contributor.author	Zheng, W
dc.date.accessioned	2023-01-18T04:14:23Z
dc.date.available	2023-01-18T04:14:23Z
dc.date.issued	2022-09-15
dc.identifier.citation	Materials Chemistry and Physics, 2022, 289
dc.identifier.issn	0254-0584
dc.identifier.issn	1879-3312
dc.identifier.uri	http://hdl.handle.net/10453/165105
dc.description.abstract	Currently drug-controlled release technology has gained a great deal of attention on the field of biomedicine. Nevertheless, most drug-controlled release systems usually require complex modification. Herein, the monolayer and multilayer structure nanofibers for drug delivery of acetylsalicylic acid (ASA), as a model drug, were fabricated using the one-step electrospinning technique for the first time, which was composed with the poly(lactic-co-glycolic acid) (PLGA) and silk fibroin (SF). Meanwhile, the effects of the mass radio of PLGA to SF on the properties of the electrospun monolayer nanofiber membrane was further investigated. The results of the electrospun monolayer PLGA-SF nanofiber membrane with mass radio of 2:1 displayed significant improvement in hydrophilicity as well as mechanical properties compared to the other mass radio of nanofibers membranes. Moreover, drug release studies revealed that nanofiber membrane with multilayer structure was able to promote a much more sustained release of ASA in comparison with monolayer PLGA-SF nanofibers membranes. More remarkable, the nanofiber membrane with multilayer structure presented good biocompatibility. Overall, these results demonstrate the potential of using PLGA-SF nanofibers with multilayer structure as a scaffold for drug-controlled release.
dc.language	English
dc.publisher	ELSEVIER SCIENCE SA
dc.relation.ispartof	Materials Chemistry and Physics
dc.relation.isbasedon	10.1016/j.matchemphys.2022.126452
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0912 Materials Engineering, 1007 Nanotechnology
dc.subject.classification	Materials
dc.title	Preparation and characterization of electrospun PLGA-SF nanofibers as a potential drug delivery system
dc.type	Journal Article
utslib.citation.volume	289
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0912 Materials Engineering
utslib.for	1007 Nanotechnology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2023-01-18T04:14:21Z
pubs.publication-status	Published
pubs.volume	289

Abstract:

Currently drug-controlled release technology has gained a great deal of attention on the field of biomedicine. Nevertheless, most drug-controlled release systems usually require complex modification. Herein, the monolayer and multilayer structure nanofibers for drug delivery of acetylsalicylic acid (ASA), as a model drug, were fabricated using the one-step electrospinning technique for the first time, which was composed with the poly(lactic-co-glycolic acid) (PLGA) and silk fibroin (SF). Meanwhile, the effects of the mass radio of PLGA to SF on the properties of the electrospun monolayer nanofiber membrane was further investigated. The results of the electrospun monolayer PLGA-SF nanofiber membrane with mass radio of 2:1 displayed significant improvement in hydrophilicity as well as mechanical properties compared to the other mass radio of nanofibers membranes. Moreover, drug release studies revealed that nanofiber membrane with multilayer structure was able to promote a much more sustained release of ASA in comparison with monolayer PLGA-SF nanofibers membranes. More remarkable, the nanofiber membrane with multilayer structure presented good biocompatibility. Overall, these results demonstrate the potential of using PLGA-SF nanofibers with multilayer structure as a scaffold for drug-controlled release.

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http://hdl.handle.net/10453/165105