Interplay of Gut Microbiota in Polycystic Ovarian Syndrome: Role of Gut Microbiota, Mechanistic Pathways and Potential Treatment Strategies

Corrie, L; Awasthi, A; Kaur, J; Vishwas, S; Gulati, M; Kaur, IP; Gupta, G; Kommineni, N; Dua, K; Singh, SK

Interplay of Gut Microbiota in Polycystic Ovarian Syndrome: Role of Gut Microbiota, Mechanistic Pathways and Potential Treatment Strategies

Corrie, L Awasthi, A Kaur, J Vishwas, S Gulati, M Kaur, IP Gupta, G Kommineni, N Dua, K

Singh, SK

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Pharmaceuticals, 16, (2), pp. 197-197

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Field	Value	Language
dc.contributor.author	Corrie, L
dc.contributor.author	Awasthi, A
dc.contributor.author	Kaur, J
dc.contributor.author	Vishwas, S
dc.contributor.author	Gulati, M
dc.contributor.author	Kaur, IP
dc.contributor.author	Gupta, G
dc.contributor.author	Kommineni, N
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Singh, SK
dc.date.accessioned	2023-01-31T19:10:19Z
dc.date.available	2023-01-31T19:10:19Z
dc.identifier.citation	Pharmaceuticals, 16, (2), pp. 197-197
dc.identifier.issn	1424-8247
dc.identifier.uri	http://hdl.handle.net/10453/165695
dc.description.abstract	<jats:p>Polycystic Ovarian Syndrome (PCOS) comprises a set of symptoms that pose significant risk factors for various diseases, including type 2 diabetes, cardiovascular disease, and cancer. Effective and safe methods to treat all the pathological symptoms of PCOS are not available. The gut microbiota has been shown to play an essential role in PCOS incidence and progression. Many dietary plants, prebiotics, and probiotics have been reported to ameliorate PCOS. Gut microbiota shows its effects in PCOS via a number of mechanistic pathways including maintenance of homeostasis, regulation of lipid and blood glucose levels. The effect of gut microbiota on PCOS has been widely reported in animal models but there are only a few reports of human studies. Increasing the diversity of gut microbiota, and up-regulating PCOS ameliorating gut microbiota are some of the ways through which prebiotics, probiotics, and polyphenols work. We present a comprehensive review on polyphenols from natural origin, probiotics, and fecal microbiota therapy that may be used to treat PCOS by modifying the gut microbiota.</jats:p>
dc.language	en
dc.publisher	MDPI AG
dc.relation.ispartof	Pharmaceuticals
dc.relation.isbasedon	10.3390/ph16020197
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.title	Interplay of Gut Microbiota in Polycystic Ovarian Syndrome: Role of Gut Microbiota, Mechanistic Pathways and Potential Treatment Strategies
dc.type	Journal Article
utslib.citation.volume	16
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
dc.date.updated	2023-01-31T19:10:15Z
pubs.issue	2
pubs.publication-status	Published online
pubs.volume	16
utslib.citation.issue	2

Abstract:

Polycystic Ovarian Syndrome (PCOS) comprises a set of symptoms that pose significant risk factors for various diseases, including type 2 diabetes, cardiovascular disease, and cancer. Effective and safe methods to treat all the pathological symptoms of PCOS are not available. The gut microbiota has been shown to play an essential role in PCOS incidence and progression. Many dietary plants, prebiotics, and probiotics have been reported to ameliorate PCOS. Gut microbiota shows its effects in PCOS via a number of mechanistic pathways including maintenance of homeostasis, regulation of lipid and blood glucose levels. The effect of gut microbiota on PCOS has been widely reported in animal models but there are only a few reports of human studies. Increasing the diversity of gut microbiota, and up-regulating PCOS ameliorating gut microbiota are some of the ways through which prebiotics, probiotics, and polyphenols work. We present a comprehensive review on polyphenols from natural origin, probiotics, and fecal microbiota therapy that may be used to treat PCOS by modifying the gut microbiota.

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http://hdl.handle.net/10453/165695