The Role of Vitamin D in the Age of COVID‐19: A Systematic Review and Meta‐Analysis
Ghasemian, R
Shamshirian, A
Heydari, K
Malekan, M
Alizadeh‐Navaei, R
Ebrahimzadeh, MA
Ebrahimi Warkiani, M
Jafarpour, H
Razavi Bazaz, S
Shahmirzadi, AR
Khodabandeh, M
Seyfari, B
Motamedzadeh, A
Dadgostar, E
Aalinezhad, M
Sedaghat, M
Razzaghi, N
Zarandi, B
Asadi, A
Naei, VY
Beheshti, R
Hessami, A
Azizi, S
Mohseni, AR
Shamshirian, D
- Publisher:
- Wiley
- Publication Type:
- Journal Article
- Citation:
- International Journal of Clinical Practice, 2021, 75, (11), pp. 1-16
- Issue Date:
- 2021-07-29
Closed Access
Filename | Description | Size | |||
---|---|---|---|---|---|
The role of vitamin D in the age of COVID-19 A systematic review and meta-analysis.pdf | 2.06 MB | Adobe PDF |
Copyright Clearance Process
- Recently Added
- In Progress
- Closed Access
This item is closed access and not available.
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Ghasemian, R | |
dc.contributor.author | Shamshirian, A | |
dc.contributor.author | Heydari, K | |
dc.contributor.author | Malekan, M | |
dc.contributor.author | Alizadeh‐Navaei, R | |
dc.contributor.author | Ebrahimzadeh, MA | |
dc.contributor.author |
Ebrahimi Warkiani, M https://orcid.org/0000-0002-4184-1944 |
|
dc.contributor.author | Jafarpour, H | |
dc.contributor.author |
Razavi Bazaz, S https://orcid.org/0000-0002-6419-3361 |
|
dc.contributor.author | Shahmirzadi, AR | |
dc.contributor.author | Khodabandeh, M | |
dc.contributor.author | Seyfari, B | |
dc.contributor.author | Motamedzadeh, A | |
dc.contributor.author | Dadgostar, E | |
dc.contributor.author | Aalinezhad, M | |
dc.contributor.author | Sedaghat, M | |
dc.contributor.author | Razzaghi, N | |
dc.contributor.author | Zarandi, B | |
dc.contributor.author | Asadi, A | |
dc.contributor.author | Naei, VY | |
dc.contributor.author | Beheshti, R | |
dc.contributor.author | Hessami, A | |
dc.contributor.author | Azizi, S | |
dc.contributor.author | Mohseni, AR | |
dc.contributor.author | Shamshirian, D | |
dc.date.accessioned | 2023-03-12T22:45:49Z | |
dc.date.available | 2021-07-26 | |
dc.date.available | 2023-03-12T22:45:49Z | |
dc.date.issued | 2021-07-29 | |
dc.identifier.citation | International Journal of Clinical Practice, 2021, 75, (11), pp. 1-16 | |
dc.identifier.issn | 1368-5031 | |
dc.identifier.issn | 1742-1241 | |
dc.identifier.uri | http://hdl.handle.net/10453/167080 | |
dc.description.abstract | Background Evidence recommends that vitamin D might be a crucial supportive agent for the immune system, mainly in cytokine response regulation against COVID-19. Hence, we carried out a systematic review and meta-analysis in order to maximise the use of everything that exists about the role of vitamin D in the COVID-19. Methods A systematic search was performed in PubMed, Scopus, Embase and Web of Science up to December 18, 2020. Studies focused on the role of vitamin D in confirmed COVID-19 patients were entered into the systematic review. Results Twenty-three studies containing 11 901 participants entered into the meta-analysis. The meta-analysis indicated that 41% of COVID-19 patients were suffering from vitamin D deficiency (95% CI, 29%-55%), and in 42% of patients, levels of vitamin D were insufficient (95% CI, 24%-63%). The serum 25-hydroxyvitamin D concentration was 20.3 ng/mL among all COVID-19 patients (95% CI, 12.1-19.8). The odds of getting infected with SARS-CoV-2 are 3.3 times higher among individuals with vitamin D deficiency (95% CI, 2.5-4.3). The chance of developing severe COVID-19 is about five times higher in patients with vitamin D deficiency (OR: 5.1, 95% CI, 2.6-10.3). There is no significant association between vitamin D status and higher mortality rates (OR: 1.6, 95% CI, 0.5-4.4). Conclusion This study found that most of the COVID-19 patients were suffering from vitamin D deficiency/insufficiency. Also, there is about three times higher chance of getting infected with SARS-CoV-2 among vitamin-D-deficient individuals and about five times higher probability of developing the severe disease in vitamin-D-deficient patients. Vitamin D deficiency showed no significant association with mortality rates in this population. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Wiley | |
dc.relation.ispartof | International Journal of Clinical Practice | |
dc.relation.isbasedon | 10.1111/ijcp.14675 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 1103 Clinical Sciences, 1117 Public Health and Health Services, 1701 Psychology | |
dc.subject.classification | General Clinical Medicine | |
dc.subject.mesh | COVID-19 | |
dc.subject.mesh | Humans | |
dc.subject.mesh | SARS-CoV-2 | |
dc.subject.mesh | Vitamin D | |
dc.subject.mesh | Vitamin D Deficiency | |
dc.subject.mesh | Vitamins | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Vitamin D Deficiency | |
dc.subject.mesh | Vitamins | |
dc.subject.mesh | Vitamin D | |
dc.subject.mesh | COVID-19 | |
dc.subject.mesh | SARS-CoV-2 | |
dc.subject.mesh | COVID-19 | |
dc.subject.mesh | Humans | |
dc.subject.mesh | SARS-CoV-2 | |
dc.subject.mesh | Vitamin D | |
dc.subject.mesh | Vitamin D Deficiency | |
dc.subject.mesh | Vitamins | |
dc.title | The Role of Vitamin D in the Age of COVID‐19: A Systematic Review and Meta‐Analysis | |
dc.type | Journal Article | |
utslib.citation.volume | 75 | |
utslib.location.activity | India | |
utslib.for | 1103 Clinical Sciences | |
utslib.for | 1117 Public Health and Health Services | |
utslib.for | 1701 Psychology | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
pubs.organisational-group | /University of Technology Sydney/Centre for Health Technologies (CHT) | |
utslib.copyright.status | closed_access | * |
pubs.consider-herdc | false | |
dc.date.updated | 2023-03-12T22:45:45Z | |
pubs.issue | 11 | |
pubs.publication-status | Published | |
pubs.volume | 75 | |
utslib.citation.issue | 11 |
Abstract:
Background
Evidence recommends that vitamin D might be a crucial supportive agent for the immune system, mainly in cytokine response regulation against COVID-19. Hence, we carried out a systematic review and meta-analysis in order to maximise the use of everything that exists about the role of vitamin D in the COVID-19.
Methods
A systematic search was performed in PubMed, Scopus, Embase and Web of Science up to December 18, 2020. Studies focused on the role of vitamin D in confirmed COVID-19 patients were entered into the systematic review.
Results
Twenty-three studies containing 11 901 participants entered into the meta-analysis. The meta-analysis indicated that 41% of COVID-19 patients were suffering from vitamin D deficiency (95% CI, 29%-55%), and in 42% of patients, levels of vitamin D were insufficient (95% CI, 24%-63%). The serum 25-hydroxyvitamin D concentration was 20.3 ng/mL among all COVID-19 patients (95% CI, 12.1-19.8). The odds of getting infected with SARS-CoV-2 are 3.3 times higher among individuals with vitamin D deficiency (95% CI, 2.5-4.3). The chance of developing severe COVID-19 is about five times higher in patients with vitamin D deficiency (OR: 5.1, 95% CI, 2.6-10.3). There is no significant association between vitamin D status and higher mortality rates (OR: 1.6, 95% CI, 0.5-4.4).
Conclusion
This study found that most of the COVID-19 patients were suffering from vitamin D deficiency/insufficiency. Also, there is about three times higher chance of getting infected with SARS-CoV-2 among vitamin-D-deficient individuals and about five times higher probability of developing the severe disease in vitamin-D-deficient patients. Vitamin D deficiency showed no significant association with mortality rates in this population.
Please use this identifier to cite or link to this item:
Download statistics for the last 12 months
Not enough data to produce graph