Single-cell analysis of circulating tumour cells: enabling technologies and clinical applications.

Radfar, P; Aboulkheyr Es, H; Salomon, R; Kulasinghe, A; Ramalingam, N; Sarafraz-Yazdi, E; Thiery, JP; Warkiani, ME

Single-cell analysis of circulating tumour cells: enabling technologies and clinical applications.

Radfar, P Aboulkheyr Es, H Salomon, R

Kulasinghe, A Ramalingam, N Sarafraz-Yazdi, E Thiery, JP Warkiani, ME

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Publisher:: ELSEVIER SCIENCE LONDON
Publication Type:: Journal Article
Citation:: Trends Biotechnol, 2022, 40, (9), pp. 1041-1060
Issue Date:: 2022-09

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Field	Value	Language
dc.contributor.author	Radfar, P
dc.contributor.author	Aboulkheyr Es, H
dc.contributor.author	Salomon, R https://orcid.org/0000-0003-4504-2901
dc.contributor.author	Kulasinghe, A
dc.contributor.author	Ramalingam, N
dc.contributor.author	Sarafraz-Yazdi, E
dc.contributor.author	Thiery, JP
dc.contributor.author	Warkiani, ME
dc.date.accessioned	2023-04-03T04:09:29Z
dc.date.available	2022-02-16
dc.date.available	2023-04-03T04:09:29Z
dc.date.issued	2022-09
dc.identifier.citation	Trends Biotechnol, 2022, 40, (9), pp. 1041-1060
dc.identifier.issn	0167-7799
dc.identifier.issn	1879-3096
dc.identifier.uri	http://hdl.handle.net/10453/169069
dc.description.abstract	Multimodal analysis of circulating tumour cells (CTCs) has the potential to provide remarkable insight for cancer development and metastasis. CTCs and CTC clusters investigation using single-cell analysis, enables researchers to gain crucial information on metastatic mechanisms and the genomic alterations responsible for drug resistance, empowering treatment, and management of cancer. Despite a plethora of CTC isolation technologies, careful attention to the strengths and weaknesses of each method should be considered in order to isolate these rare cells. Here, we provide an overview of cutting-edge technologies used for single-cell isolation and analysis of CTCs. Additionally, we highlight the biological features, clinical application, and the therapeutic potential of CTCs and CTC clusters using single-cell analysis platforms for cancer management.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCIENCE LONDON
dc.relation	http://purl.org/au-research/grants/arc/DP200101860
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1143377
dc.relation.ispartof	Trends Biotechnol
dc.relation.isbasedon	10.1016/j.tibtech.2022.02.004
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	06 Biological Sciences, 09 Engineering, 10 Technology
dc.subject.classification	Biotechnology
dc.subject.mesh	Cell Separation
dc.subject.mesh	Humans
dc.subject.mesh	Neoplastic Cells, Circulating
dc.subject.mesh	Single-Cell Analysis
dc.subject.mesh	Humans
dc.subject.mesh	Cell Separation
dc.subject.mesh	Neoplastic Cells, Circulating
dc.subject.mesh	Single-Cell Analysis
dc.subject.mesh	Cell Separation
dc.subject.mesh	Humans
dc.subject.mesh	Neoplastic Cells, Circulating
dc.subject.mesh	Single-Cell Analysis
dc.title	Single-cell analysis of circulating tumour cells: enabling technologies and clinical applications.
dc.type	Journal Article
utslib.citation.volume	40
utslib.location.activity	England
utslib.for	06 Biological Sciences
utslib.for	09 Engineering
utslib.for	10 Technology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2023-09-01T00:00:00+1000Z
dc.date.updated	2023-04-03T04:09:27Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	40
utslib.citation.issue	9

Abstract:

Multimodal analysis of circulating tumour cells (CTCs) has the potential to provide remarkable insight for cancer development and metastasis. CTCs and CTC clusters investigation using single-cell analysis, enables researchers to gain crucial information on metastatic mechanisms and the genomic alterations responsible for drug resistance, empowering treatment, and management of cancer. Despite a plethora of CTC isolation technologies, careful attention to the strengths and weaknesses of each method should be considered in order to isolate these rare cells. Here, we provide an overview of cutting-edge technologies used for single-cell isolation and analysis of CTCs. Additionally, we highlight the biological features, clinical application, and the therapeutic potential of CTCs and CTC clusters using single-cell analysis platforms for cancer management.

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http://hdl.handle.net/10453/169069