Hepatogenesis and hepatocarcinogenesis: Alignment of the main signaling pathways

Shokouhian, B; Es, HA; Negahdari, B; Tamimi, A; Shahdoust, M; Shpichka, A; Timashev, P; Hassan, M; Vosough, M

Hepatogenesis and hepatocarcinogenesis: Alignment of the main signaling pathways

Shokouhian, B Es, HA Negahdari, B Tamimi, A Shahdoust, M Shpichka, A Timashev, P Hassan, M Vosough, M

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Journal of Cellular Physiology, 2022, 237, (11), pp. 3984-4000
Issue Date:: 2022-08-29

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Field	Value	Language
dc.contributor.author	Shokouhian, B
dc.contributor.author	Es, HA
dc.contributor.author	Negahdari, B
dc.contributor.author	Tamimi, A
dc.contributor.author	Shahdoust, M
dc.contributor.author	Shpichka, A
dc.contributor.author	Timashev, P
dc.contributor.author	Hassan, M
dc.contributor.author	Vosough, M
dc.date.accessioned	2023-05-25T03:45:20Z
dc.date.available	2022-08-10
dc.date.available	2023-05-25T03:45:20Z
dc.date.issued	2022-08-29
dc.identifier.citation	Journal of Cellular Physiology, 2022, 237, (11), pp. 3984-4000
dc.identifier.issn	0021-9541
dc.identifier.issn	1097-4652
dc.identifier.uri	http://hdl.handle.net/10453/170456
dc.description.abstract	Development is a symphony of cells differentiation in which different signaling pathways are orchestrated at specific times and periods to form mature and functional cells from undifferentiated cells. The similarity of the gene expression profile in malignant and undifferentiated cells is an interesting topic that has been proposed for many years and gave rise to the differentiation-therapy concept, which appears a rational insight and should be reconsidered. Hepatocellular carcinoma (HCC), as the sixth common cancer and the third leading cause of cancer death worldwide, is one of the health-threatening complications in communities where hepatotropic viruses are endemic. Sedentary lifestyle and high intake of calories are other risk factors. HCC is a complex condition in which various dimensions must be addressed, including heterogeneity of cells in the tumor mass, high invasiveness, and underlying diseases that limit the treatment options. Under these restrictions, recognizing, and targeting common signaling pathways during liver development and HCC could expedite to a rational therapeutic approach, reprograming malignant cells to well-differentiated ones in a functional state. Accordingly, in this review, we highlighted the commonalities of signaling pathways in hepatogenesis and hepatocarcinogenesis, and comprised an update on the current status of targeting these pathways in laboratory studies and clinical trials.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Journal of Cellular Physiology
dc.relation.isbasedon	10.1002/jcp.30862
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology, 1116 Medical Physiology
dc.subject.classification	Biochemistry & Molecular Biology
dc.subject.mesh	Humans
dc.subject.mesh	Carcinoma, Hepatocellular
dc.subject.mesh	Liver Neoplasms
dc.subject.mesh	Carcinogenesis
dc.subject.mesh	Signal Transduction
dc.subject.mesh	Humans
dc.subject.mesh	Carcinoma, Hepatocellular
dc.subject.mesh	Liver Neoplasms
dc.subject.mesh	Signal Transduction
dc.subject.mesh	Carcinogenesis
dc.subject.mesh	Humans
dc.subject.mesh	Carcinoma, Hepatocellular
dc.subject.mesh	Liver Neoplasms
dc.subject.mesh	Carcinogenesis
dc.subject.mesh	Signal Transduction
dc.title	Hepatogenesis and hepatocarcinogenesis: Alignment of the main signaling pathways
dc.type	Journal Article
utslib.citation.volume	237
utslib.location.activity	United States
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1116 Medical Physiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2023-05-25T03:45:17Z
pubs.issue	11
pubs.publication-status	Published
pubs.volume	237
utslib.citation.issue	11

Abstract:

Development is a symphony of cells differentiation in which different signaling pathways are orchestrated at specific times and periods to form mature and functional cells from undifferentiated cells. The similarity of the gene expression profile in malignant and undifferentiated cells is an interesting topic that has been proposed for many years and gave rise to the differentiation-therapy concept, which appears a rational insight and should be reconsidered. Hepatocellular carcinoma (HCC), as the sixth common cancer and the third leading cause of cancer death worldwide, is one of the health-threatening complications in communities where hepatotropic viruses are endemic. Sedentary lifestyle and high intake of calories are other risk factors. HCC is a complex condition in which various dimensions must be addressed, including heterogeneity of cells in the tumor mass, high invasiveness, and underlying diseases that limit the treatment options. Under these restrictions, recognizing, and targeting common signaling pathways during liver development and HCC could expedite to a rational therapeutic approach, reprograming malignant cells to well-differentiated ones in a functional state. Accordingly, in this review, we highlighted the commonalities of signaling pathways in hepatogenesis and hepatocarcinogenesis, and comprised an update on the current status of targeting these pathways in laboratory studies and clinical trials.

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http://hdl.handle.net/10453/170456