Molecular pathogenesis of Chlamydia trachomatis

Jury, B; Fleming, C; Huston, WM; Luu, LDW

Molecular pathogenesis of Chlamydia trachomatis

Jury, B Fleming, C Huston, WM Luu, LDW

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Publisher:: Frontiers Media SA
Publication Type:: Journal Article
Citation:: Frontiers in Cellular and Infection Microbiology, 13, pp. 1281823

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Field	Value	Language
dc.contributor.author	Jury, B
dc.contributor.author	Fleming, C
dc.contributor.author	Huston, WM
dc.contributor.author	Luu, LDW
dc.date.accessioned	2023-10-25T02:40:13Z
dc.date.available	2023-10-25T02:40:13Z
dc.identifier.citation	Frontiers in Cellular and Infection Microbiology, 13, pp. 1281823
dc.identifier.issn	2235-2988
dc.identifier.issn	2235-2988
dc.identifier.uri	http://hdl.handle.net/10453/172846
dc.description.abstract	<jats:p><jats:italic>Chlamydia trachomatis</jats:italic> is a strict intracellular human pathogen. It is the main bacterial cause of sexually transmitted infections and the etiologic agent of trachoma, which is the leading cause of preventable blindness. Despite over 100 years since <jats:italic>C. trachomatis</jats:italic> was first identified, there is still no vaccine. However in recent years, the advancement of genetic manipulation approaches for <jats:italic>C. trachomatis</jats:italic> has increased our understanding of the molecular pathogenesis of <jats:italic>C. trachomatis</jats:italic> and progress towards a vaccine. In this mini-review, we aimed to outline the factors related to the developmental cycle phase and specific pathogenesis activity of <jats:italic>C. trachomatis</jats:italic> in order to focus priorities for future genetic approaches. We highlight the factors known to be critical for developmental cycle stages, gene expression regulatory factors, type III secretion system and their effectors, and individual virulence factors with known impacts.</jats:p>
dc.language	en
dc.publisher	Frontiers Media SA
dc.relation.ispartof	Frontiers in Cellular and Infection Microbiology
dc.relation.isbasedon	10.3389/fcimb.2023.1281823
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0601 Biochemistry and Cell Biology, 0605 Microbiology
dc.subject.classification	3107 Microbiology
dc.subject.classification	3207 Medical microbiology
dc.title	Molecular pathogenesis of Chlamydia trachomatis
dc.type	Journal Article
utslib.citation.volume	13
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	0605 Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	open_access	*
dc.date.updated	2023-10-25T02:40:11Z
pubs.publication-status	Published online
pubs.volume	13

Abstract:

Chlamydia trachomatis is a strict intracellular human pathogen. It is the main bacterial cause of sexually transmitted infections and the etiologic agent of trachoma, which is the leading cause of preventable blindness. Despite over 100 years since C. trachomatis was first identified, there is still no vaccine. However in recent years, the advancement of genetic manipulation approaches for C. trachomatis has increased our understanding of the molecular pathogenesis of C. trachomatis and progress towards a vaccine. In this mini-review, we aimed to outline the factors related to the developmental cycle phase and specific pathogenesis activity of C. trachomatis in order to focus priorities for future genetic approaches. We highlight the factors known to be critical for developmental cycle stages, gene expression regulatory factors, type III secretion system and their effectors, and individual virulence factors with known impacts.

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http://hdl.handle.net/10453/172846