Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development.

Mehta, M; Bui, TA; Yang, X; Aksoy, Y; Goldys, EM; Deng, W

Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development.

Mehta, M Bui, TA Yang, X Aksoy, Y Goldys, EM Deng, W

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Publisher:: AMER CHEMICAL SOC
Publication Type:: Journal Article
Citation:: ACS Mater Au, 2023, 3, (6), pp. 600-619
Issue Date:: 2023-11-08

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Field	Value	Language
dc.contributor.author	Mehta, M
dc.contributor.author	Bui, TA
dc.contributor.author	Yang, X
dc.contributor.author	Aksoy, Y
dc.contributor.author	Goldys, EM
dc.contributor.author	Deng, W https://orcid.org/0000-0002-9413-0978
dc.date.accessioned	2024-01-16T04:22:27Z
dc.date.available	2023-08-15
dc.date.available	2024-01-16T04:22:27Z
dc.date.issued	2023-11-08
dc.identifier.citation	ACS Mater Au, 2023, 3, (6), pp. 600-619
dc.identifier.issn	2694-2461
dc.identifier.issn	2694-2461
dc.identifier.uri	http://hdl.handle.net/10453/174575
dc.description.abstract	Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and promising therapeutic outcomes, thus gaining substantial interest in preclinical and clinical research. In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid polymer hybrid nanoparticles, focusing on their main physicochemical properties and therapeutic potential. We discuss computational studies and modeling techniques to enhance the understanding of how LNPs interact with therapeutic cargo and to predict the potential effectiveness of such interactions in therapeutic applications. We also analyze the benefits and drawbacks of various LNP production techniques such as nanoprecipitation, emulsification, evaporation, thin film hydration, microfluidic-based methods, and an impingement jet mixer. Additionally, we discuss the major challenges associated with industrial development, including stability and sterilization, storage, regulatory compliance, reproducibility, and quality control. Overcoming these challenges and facilitating regulatory compliance represent the key steps toward LNP's successful commercialization and translation into clinical settings.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	AMER CHEMICAL SOC
dc.relation	http://purl.org/au-research/grants/nhmrc/1181889
dc.relation.ispartof	ACS Mater Au
dc.relation.isbasedon	10.1021/acsmaterialsau.3c00032
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development.
dc.type	Journal Article
utslib.citation.volume	3
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2024-01-16T04:22:25Z
pubs.issue	6
pubs.publication-status	Published online
pubs.volume	3
utslib.citation.issue	6

Abstract:

Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and promising therapeutic outcomes, thus gaining substantial interest in preclinical and clinical research. In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid polymer hybrid nanoparticles, focusing on their main physicochemical properties and therapeutic potential. We discuss computational studies and modeling techniques to enhance the understanding of how LNPs interact with therapeutic cargo and to predict the potential effectiveness of such interactions in therapeutic applications. We also analyze the benefits and drawbacks of various LNP production techniques such as nanoprecipitation, emulsification, evaporation, thin film hydration, microfluidic-based methods, and an impingement jet mixer. Additionally, we discuss the major challenges associated with industrial development, including stability and sterilization, storage, regulatory compliance, reproducibility, and quality control. Overcoming these challenges and facilitating regulatory compliance represent the key steps toward LNP's successful commercialization and translation into clinical settings.

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http://hdl.handle.net/10453/174575