Novel Movable Typing for Personalized Vein-Chips in Large Scale: Recapitulate Patient-Specific Virchow's Triad and its Contribution to Cerebral Venous Sinus Thrombosis

Zhao, YC; Zhang, Y; Wang, Z; Jiang, F; Kyanian, K; Aye, SSS; Hong, T; Vatankhah, P; Nasser, A; Sun, A; Moldovan, L; Su, QP; Cho, AN; Wang, Y; Passam, F; Ang, T; Ju, LA

Novel Movable Typing for Personalized Vein-Chips in Large Scale: Recapitulate Patient-Specific Virchow's Triad and its Contribution to Cerebral Venous Sinus Thrombosis

Zhao, YC Zhang, Y Wang, Z Jiang, F Kyanian, K Aye, SSS Hong, T Vatankhah, P Nasser, A Sun, A Moldovan, L Su, QP Cho, AN Wang, Y Passam, F Ang, T Ju, LA

Permalink

Publisher:: WILEY-V C H VERLAG GMBH
Publication Type:: Journal Article
Citation:: Advanced Functional Materials, 2023, 33, (23)
Issue Date:: 2023-06-02

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published versionAdobe PDF (4.4 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Zhao, YC
dc.contributor.author	Zhang, Y
dc.contributor.author	Wang, Z
dc.contributor.author	Jiang, F
dc.contributor.author	Kyanian, K
dc.contributor.author	Aye, SSS
dc.contributor.author	Hong, T
dc.contributor.author	Vatankhah, P
dc.contributor.author	Nasser, A
dc.contributor.author	Sun, A
dc.contributor.author	Moldovan, L
dc.contributor.author	Su, QP
dc.contributor.author	Cho, AN
dc.contributor.author	Wang, Y
dc.contributor.author	Passam, F
dc.contributor.author	Ang, T
dc.contributor.author	Ju, LA
dc.date.accessioned	2024-04-29T08:45:48Z
dc.date.available	2024-04-29T08:45:48Z
dc.date.issued	2023-06-02
dc.identifier.citation	Advanced Functional Materials, 2023, 33, (23)
dc.identifier.issn	1616-301X
dc.identifier.issn	1616-3028
dc.identifier.uri	http://hdl.handle.net/10453/178472
dc.description.abstract	The Vein-Chip recapitulates CVST Virchow's triad and enables systematic characterization of venous thrombogenesis with respect to fibrin formation and platelet aggregation. Distinct from the arterial setting, platelets universally adhere across the entire CVS Vein-Chip independent of stenotic geometry and flow disturbance. Intriguingly, fibrin propagates along with the flow direction, but exclusively deposits to the inner vessel wall. Upon inflammatory endothelial injury, fibrin deposition mirrors to the outer vessel wall, but still not in the lumen. Together, the Vein-Chip promises future applications for personalized thrombotic assessment and monitoring.
dc.language	English
dc.publisher	WILEY-V C H VERLAG GMBH
dc.relation	http://purl.org/au-research/grants/arc/DP200101970
dc.relation.ispartof	Advanced Functional Materials
dc.relation.isbasedon	10.1002/adfm.202214179
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	02 Physical Sciences, 03 Chemical Sciences, 09 Engineering
dc.subject.classification	Materials
dc.subject.classification	34 Chemical sciences
dc.subject.classification	40 Engineering
dc.subject.classification	51 Physical sciences
dc.title	Novel Movable Typing for Personalized Vein-Chips in Large Scale: Recapitulate Patient-Specific Virchow's Triad and its Contribution to Cerebral Venous Sinus Thrombosis
dc.type	Journal Article
utslib.citation.volume	33
utslib.for	02 Physical Sciences
utslib.for	03 Chemical Sciences
utslib.for	09 Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2024-04-29T08:45:46Z
pubs.issue	23
pubs.publication-status	Published
pubs.volume	33
utslib.citation.issue	23

Abstract:

The Vein-Chip recapitulates CVST Virchow's triad and enables systematic characterization of venous thrombogenesis with respect to fibrin formation and platelet aggregation. Distinct from the arterial setting, platelets universally adhere across the entire CVS Vein-Chip independent of stenotic geometry and flow disturbance. Intriguingly, fibrin propagates along with the flow direction, but exclusively deposits to the inner vessel wall. Upon inflammatory endothelial injury, fibrin deposition mirrors to the outer vessel wall, but still not in the lumen. Together, the Vein-Chip promises future applications for personalized thrombotic assessment and monitoring.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/178472