Contributors to impaired bone health in type 2 diabetes.

Sheu, A; Greenfield, JR; White, CP; Center, JR

Contributors to impaired bone health in type 2 diabetes.

Sheu, A Greenfield, JR White, CP Center, JR

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Trends Endocrinol Metab, 2023, 34, (1), pp. 34-48
Issue Date:: 2023-01

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Field	Value	Language
dc.contributor.author	Sheu, A
dc.contributor.author	Greenfield, JR
dc.contributor.author	White, CP
dc.contributor.author	Center, JR
dc.date.accessioned	2024-06-24T22:31:58Z
dc.date.available	2022-11-04
dc.date.available	2024-06-24T22:31:58Z
dc.date.issued	2023-01
dc.identifier.citation	Trends Endocrinol Metab, 2023, 34, (1), pp. 34-48
dc.identifier.issn	1043-2760
dc.identifier.issn	1879-3061
dc.identifier.uri	http://hdl.handle.net/10453/179636
dc.description.abstract	Type 2 diabetes (T2D) is associated with numerous complications, including increased risk of fragility fractures, despite seemingly protective factors [e.g., normal bone mineral density and increased body mass index(BMI)]. However, fracture risk in T2D is underestimated by current fracture risk calculators. Importantly, post-fracture mortality is worse in T2D following any fracture, highlighting the importance of identifying high-risk patients that may benefit from targeted management. Several diabetes-related factors are associated with increased fracture risk, including exogenous insulin therapy, vascular complications, and poor glycaemic control, although detailed comprehensive studies to identify the independent contributions of these factors are lacking. The underlying pathophysiological mechanisms are complex and multifactorial, with different factors contributing during the course of T2D disease. These include obesity, hyperinsulinaemia, hyperglycaemia, accumulation of advanced glycation end products, and vascular supply affecting bone-cell function and survival and bone-matrix composition. This review summarises the current understanding of the contributors to impaired bone health in T2D, and proposes an updated approach to managing these patients.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Trends Endocrinol Metab
dc.relation.isbasedon	10.1016/j.tem.2022.11.003
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine
dc.subject.classification	Endocrinology & Metabolism
dc.subject.classification	3215 Reproductive medicine
dc.subject.mesh	Humans
dc.subject.mesh	Diabetes Mellitus, Type 2
dc.subject.mesh	Bone Density
dc.subject.mesh	Bone and Bones
dc.subject.mesh	Fractures, Bone
dc.subject.mesh	Glycation End Products, Advanced
dc.subject.mesh	Hyperglycemia
dc.subject.mesh	Bone and Bones
dc.subject.mesh	Humans
dc.subject.mesh	Diabetes Mellitus, Type 2
dc.subject.mesh	Hyperglycemia
dc.subject.mesh	Bone Density
dc.subject.mesh	Fractures, Bone
dc.subject.mesh	Glycation End Products, Advanced
dc.subject.mesh	Humans
dc.subject.mesh	Diabetes Mellitus, Type 2
dc.subject.mesh	Bone Density
dc.subject.mesh	Bone and Bones
dc.subject.mesh	Fractures, Bone
dc.subject.mesh	Glycation End Products, Advanced
dc.subject.mesh	Hyperglycemia
dc.title	Contributors to impaired bone health in type 2 diabetes.
dc.type	Journal Article
utslib.citation.volume	34
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
utslib.for	1114 Paediatrics and Reproductive Medicine
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2024-06-24T22:31:56Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	34
utslib.citation.issue	1

Abstract:

Type 2 diabetes (T2D) is associated with numerous complications, including increased risk of fragility fractures, despite seemingly protective factors [e.g., normal bone mineral density and increased body mass index(BMI)]. However, fracture risk in T2D is underestimated by current fracture risk calculators. Importantly, post-fracture mortality is worse in T2D following any fracture, highlighting the importance of identifying high-risk patients that may benefit from targeted management. Several diabetes-related factors are associated with increased fracture risk, including exogenous insulin therapy, vascular complications, and poor glycaemic control, although detailed comprehensive studies to identify the independent contributions of these factors are lacking. The underlying pathophysiological mechanisms are complex and multifactorial, with different factors contributing during the course of T2D disease. These include obesity, hyperinsulinaemia, hyperglycaemia, accumulation of advanced glycation end products, and vascular supply affecting bone-cell function and survival and bone-matrix composition. This review summarises the current understanding of the contributors to impaired bone health in T2D, and proposes an updated approach to managing these patients.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/179636