3D bioprinting approaches for spinal cord injury repair.
- Publisher:
- IOP Publishing Ltd
- Publication Type:
- Journal Article
- Citation:
- Biofabrication, 2024, 16, (3)
- Issue Date:
- 2024-04-22
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Jiu_2024_Biofabrication_16_032003.pdf | Published version | 1.88 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Jiu, J | |
dc.contributor.author | Liu, H | |
dc.contributor.author | Li, D | |
dc.contributor.author |
Li, J https://orcid.org/0000-0002-3584-6765 |
|
dc.contributor.author | Liu, L | |
dc.contributor.author | Yang, W | |
dc.contributor.author | Yan, L | |
dc.contributor.author | Li, S | |
dc.contributor.author | Zhang, J | |
dc.contributor.author | Li, X | |
dc.contributor.author | Li, JJ | |
dc.contributor.author | Wang, B | |
dc.date.accessioned | 2024-07-31T23:13:03Z | |
dc.date.available | 2024-04-03 | |
dc.date.available | 2024-07-31T23:13:03Z | |
dc.date.issued | 2024-04-22 | |
dc.identifier.citation | Biofabrication, 2024, 16, (3) | |
dc.identifier.issn | 1758-5082 | |
dc.identifier.issn | 1758-5090 | |
dc.identifier.uri | http://hdl.handle.net/10453/179887 | |
dc.description.abstract | Regenerative healing of spinal cord injury (SCI) poses an ongoing medical challenge by causing persistent neurological impairment and a significant socioeconomic burden. The complexity of spinal cord tissue presents hurdles to successful regeneration following injury, due to the difficulty of forming a biomimetic structure that faithfully replicates native tissue using conventional tissue engineering scaffolds. 3D bioprinting is a rapidly evolving technology with unmatched potential to create 3D biological tissues with complicated and hierarchical structure and composition. With the addition of biological additives such as cells and biomolecules, 3D bioprinting can fabricate preclinical implants, tissue or organ-like constructs, andin vitromodels through precise control over the deposition of biomaterials and other building blocks. This review highlights the characteristics and advantages of 3D bioprinting for scaffold fabrication to enable SCI repair, including bottom-up manufacturing, mechanical customization, and spatial heterogeneity. This review also critically discusses the impact of various fabrication parameters on the efficacy of spinal cord repair using 3D bioprinted scaffolds, including the choice of printing method, scaffold shape, biomaterials, and biological supplements such as cells and growth factors. High-quality preclinical studies are required to accelerate the translation of 3D bioprinting into clinical practice for spinal cord repair. Meanwhile, other technological advances will continue to improve the regenerative capability of bioprinted scaffolds, such as the incorporation of nanoscale biological particles and the development of 4D printing. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | IOP Publishing Ltd | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1120249 | |
dc.relation.ispartof | Biofabrication | |
dc.relation.isbasedon | 10.1088/1758-5090/ad3a13 | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | 0903 Biomedical Engineering, 1004 Medical Biotechnology, 1099 Other Technology | |
dc.subject.classification | 3206 Medical biotechnology | |
dc.subject.classification | 4003 Biomedical engineering | |
dc.subject.mesh | Spinal Cord Injuries | |
dc.subject.mesh | Printing, Three-Dimensional | |
dc.subject.mesh | Bioprinting | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Tissue Scaffolds | |
dc.subject.mesh | Tissue Engineering | |
dc.subject.mesh | Biocompatible Materials | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Spinal Cord Injuries | |
dc.subject.mesh | Biocompatible Materials | |
dc.subject.mesh | Tissue Engineering | |
dc.subject.mesh | Tissue Scaffolds | |
dc.subject.mesh | Bioprinting | |
dc.subject.mesh | Printing, Three-Dimensional | |
dc.subject.mesh | Spinal Cord Injuries | |
dc.subject.mesh | Printing, Three-Dimensional | |
dc.subject.mesh | Bioprinting | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Tissue Scaffolds | |
dc.subject.mesh | Tissue Engineering | |
dc.subject.mesh | Biocompatible Materials | |
dc.title | 3D bioprinting approaches for spinal cord injury repair. | |
dc.type | Journal Article | |
utslib.citation.volume | 16 | |
utslib.location.activity | England | |
utslib.for | 0903 Biomedical Engineering | |
utslib.for | 1004 Medical Biotechnology | |
utslib.for | 1099 Other Technology | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
utslib.copyright.status | in_progress | * |
dc.date.updated | 2024-07-31T23:12:58Z | |
pubs.issue | 3 | |
pubs.publication-status | Published online | |
pubs.volume | 16 | |
utslib.citation.issue | 3 |
Abstract:
Regenerative healing of spinal cord injury (SCI) poses an ongoing medical challenge by causing persistent neurological impairment and a significant socioeconomic burden. The complexity of spinal cord tissue presents hurdles to successful regeneration following injury, due to the difficulty of forming a biomimetic structure that faithfully replicates native tissue using conventional tissue engineering scaffolds. 3D bioprinting is a rapidly evolving technology with unmatched potential to create 3D biological tissues with complicated and hierarchical structure and composition. With the addition of biological additives such as cells and biomolecules, 3D bioprinting can fabricate preclinical implants, tissue or organ-like constructs, andin vitromodels through precise control over the deposition of biomaterials and other building blocks. This review highlights the characteristics and advantages of 3D bioprinting for scaffold fabrication to enable SCI repair, including bottom-up manufacturing, mechanical customization, and spatial heterogeneity. This review also critically discusses the impact of various fabrication parameters on the efficacy of spinal cord repair using 3D bioprinted scaffolds, including the choice of printing method, scaffold shape, biomaterials, and biological supplements such as cells and growth factors. High-quality preclinical studies are required to accelerate the translation of 3D bioprinting into clinical practice for spinal cord repair. Meanwhile, other technological advances will continue to improve the regenerative capability of bioprinted scaffolds, such as the incorporation of nanoscale biological particles and the development of 4D printing.
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