Ångstrom-scale gold particles loaded with alendronate via alpha-lipoic acid alleviate bone loss in osteoporotic mice.
- Publisher:
- BMC
- Publication Type:
- Journal Article
- Citation:
- J Nanobiotechnology, 2024, 22, (1), pp. 212
- Issue Date:
- 2024-04-30
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Gao, W | |
dc.contributor.author | Li, JJ | |
dc.contributor.author | Shi, J | |
dc.contributor.author | Lan, H | |
dc.contributor.author | Guo, Y | |
dc.contributor.author | Fu, D | |
dc.date.accessioned | 2024-08-01T04:34:03Z | |
dc.date.available | 2024-04-04 | |
dc.date.available | 2024-08-01T04:34:03Z | |
dc.date.issued | 2024-04-30 | |
dc.identifier.citation | J Nanobiotechnology, 2024, 22, (1), pp. 212 | |
dc.identifier.issn | 1477-3155 | |
dc.identifier.issn | 1477-3155 | |
dc.identifier.uri | http://hdl.handle.net/10453/179941 | |
dc.description.abstract | Osteoporosis is a highly prevalent metabolic disease characterized by low systemic bone mass and deterioration of bone microarchitecture, resulting in reduced bone strength and increased fracture risk. Current treatment options for osteoporosis are limited by factors such as efficacy, cost, availability, side effects, and acceptability to patients. Gold nanoparticles show promise as an emerging osteoporosis therapy due to their osteogenic effects and ability to allow therapeutic delivery but have inherent constraints, such as low specificity and the potential for heavy metal accumulation in the body. This study reports the synthesis of ultrasmall gold particles almost reaching the Ångstrom (Ång) dimension. The antioxidant alpha-lipoic acid (LA) is used as a dispersant and stabilizer to coat Ångstrom-scale gold particles (AuÅPs). Alendronate (AL), an amino-bisphosphonate commonly used in drug therapy for osteoporosis, is conjugated through LA to the surface of AuÅPs, allowing targeted delivery to bone and enhancing antiresorptive therapeutic effects. In this study, alendronate-loaded Ångstrom-scale gold particles (AuÅPs-AL) were used for the first time to promote osteogenesis and alleviate bone loss through regulation of the WNT signaling pathway, as shown through in vitro tests. The in vivo therapeutic effects of AuÅPs-AL were demonstrated in an established osteoporosis mouse model. The results of Micro-computed Tomography, histology, and tartrate-resistant acid phosphatase staining indicated that AuÅPs-AL significantly improved bone density and prevented bone loss, with no evidence of nanoparticle-associated toxicity. These findings suggest the possible future application of AuÅPs-AL in osteoporosis therapy and point to the potential of developing new approaches for treating metabolic bone diseases using Ångstrom-scale gold particles. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | BMC | |
dc.relation.ispartof | J Nanobiotechnology | |
dc.relation.isbasedon | 10.1186/s12951-024-02466-9 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 10 Technology | |
dc.subject.classification | Nanoscience & Nanotechnology | |
dc.subject.classification | 3001 Agricultural biotechnology | |
dc.subject.classification | 3106 Industrial biotechnology | |
dc.subject.classification | 3206 Medical biotechnology | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Alendronate | |
dc.subject.mesh | Thioctic Acid | |
dc.subject.mesh | Gold | |
dc.subject.mesh | Osteoporosis | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Metal Nanoparticles | |
dc.subject.mesh | Female | |
dc.subject.mesh | Osteogenesis | |
dc.subject.mesh | Mice, Inbred C57BL | |
dc.subject.mesh | Bone Density Conservation Agents | |
dc.subject.mesh | Particle Size | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Mice, Inbred C57BL | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Osteoporosis | |
dc.subject.mesh | Gold | |
dc.subject.mesh | Alendronate | |
dc.subject.mesh | Thioctic Acid | |
dc.subject.mesh | Osteogenesis | |
dc.subject.mesh | Particle Size | |
dc.subject.mesh | Female | |
dc.subject.mesh | Bone Density Conservation Agents | |
dc.subject.mesh | Metal Nanoparticles | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Alendronate | |
dc.subject.mesh | Thioctic Acid | |
dc.subject.mesh | Gold | |
dc.subject.mesh | Osteoporosis | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Metal Nanoparticles | |
dc.subject.mesh | Female | |
dc.subject.mesh | Osteogenesis | |
dc.subject.mesh | Mice, Inbred C57BL | |
dc.subject.mesh | Bone Density Conservation Agents | |
dc.subject.mesh | Particle Size | |
dc.title | Ångstrom-scale gold particles loaded with alendronate via alpha-lipoic acid alleviate bone loss in osteoporotic mice. | |
dc.type | Journal Article | |
utslib.citation.volume | 22 | |
utslib.location.activity | England | |
utslib.for | 10 Technology | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
utslib.copyright.status | open_access | * |
dc.rights.license | This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2024-08-01T04:33:51Z | |
pubs.issue | 1 | |
pubs.publication-status | Published online | |
pubs.volume | 22 | |
utslib.citation.issue | 1 |
Abstract:
Osteoporosis is a highly prevalent metabolic disease characterized by low systemic bone mass and deterioration of bone microarchitecture, resulting in reduced bone strength and increased fracture risk. Current treatment options for osteoporosis are limited by factors such as efficacy, cost, availability, side effects, and acceptability to patients. Gold nanoparticles show promise as an emerging osteoporosis therapy due to their osteogenic effects and ability to allow therapeutic delivery but have inherent constraints, such as low specificity and the potential for heavy metal accumulation in the body. This study reports the synthesis of ultrasmall gold particles almost reaching the Ångstrom (Ång) dimension. The antioxidant alpha-lipoic acid (LA) is used as a dispersant and stabilizer to coat Ångstrom-scale gold particles (AuÅPs). Alendronate (AL), an amino-bisphosphonate commonly used in drug therapy for osteoporosis, is conjugated through LA to the surface of AuÅPs, allowing targeted delivery to bone and enhancing antiresorptive therapeutic effects. In this study, alendronate-loaded Ångstrom-scale gold particles (AuÅPs-AL) were used for the first time to promote osteogenesis and alleviate bone loss through regulation of the WNT signaling pathway, as shown through in vitro tests. The in vivo therapeutic effects of AuÅPs-AL were demonstrated in an established osteoporosis mouse model. The results of Micro-computed Tomography, histology, and tartrate-resistant acid phosphatase staining indicated that AuÅPs-AL significantly improved bone density and prevented bone loss, with no evidence of nanoparticle-associated toxicity. These findings suggest the possible future application of AuÅPs-AL in osteoporosis therapy and point to the potential of developing new approaches for treating metabolic bone diseases using Ångstrom-scale gold particles.
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