Nanoscale insights into hematology: super-resolved imaging on blood cell structure, function, and pathology.
- Publisher:
- Springer Nature
- Publication Type:
- Journal Article
- Citation:
- J Nanobiotechnology, 2024, 22, (1), pp. 363
- Issue Date:
- 2024-06-24
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, J | |
dc.contributor.author | Tan, YY | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Wang, Y | |
dc.contributor.author | Ju, LA | |
dc.contributor.author | Su, QP | |
dc.date.accessioned | 2024-08-01T04:42:11Z | |
dc.date.available | 2024-05-30 | |
dc.date.available | 2024-08-01T04:42:11Z | |
dc.date.issued | 2024-06-24 | |
dc.identifier.citation | J Nanobiotechnology, 2024, 22, (1), pp. 363 | |
dc.identifier.issn | 1477-3155 | |
dc.identifier.issn | 1477-3155 | |
dc.identifier.uri | http://hdl.handle.net/10453/179959 | |
dc.description.abstract | Fluorescence nanoscopy, also known as super-resolution microscopy, has transcended the conventional resolution barriers and enabled visualization of biological samples at nanometric resolutions. A series of super-resolution techniques have been developed and applied to investigate the molecular distribution, organization, and interactions in blood cells, as well as the underlying mechanisms of blood-cell-associated diseases. In this review, we provide an overview of various fluorescence nanoscopy technologies, outlining their current development stage and the challenges they are facing in terms of functionality and practicality. We specifically explore how these innovations have propelled forward the analysis of thrombocytes (platelets), erythrocytes (red blood cells) and leukocytes (white blood cells), shedding light on the nanoscale arrangement of subcellular components and molecular interactions. We spotlight novel biomarkers uncovered by fluorescence nanoscopy for disease diagnosis, such as thrombocytopathies, malignancies, and infectious diseases. Furthermore, we discuss the technological hurdles and chart out prospective avenues for future research directions. This review aims to underscore the significant contributions of fluorescence nanoscopy to the field of blood cell analysis and disease diagnosis, poised to revolutionize our approach to exploring, understanding, and managing disease at the molecular level. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | Springer Nature | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1177374 | |
dc.relation.ispartof | J Nanobiotechnology | |
dc.relation.isbasedon | 10.1186/s12951-024-02605-2 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 10 Technology | |
dc.subject.classification | Nanoscience & Nanotechnology | |
dc.subject.classification | 3001 Agricultural biotechnology | |
dc.subject.classification | 3106 Industrial biotechnology | |
dc.subject.classification | 3206 Medical biotechnology | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Blood Cells | |
dc.subject.mesh | Blood Platelets | |
dc.subject.mesh | Erythrocytes | |
dc.subject.mesh | Hematology | |
dc.subject.mesh | Leukocytes | |
dc.subject.mesh | Microscopy, Fluorescence | |
dc.subject.mesh | Nanotechnology | |
dc.subject.mesh | Blood Cells | |
dc.subject.mesh | Blood Platelets | |
dc.subject.mesh | Erythrocytes | |
dc.subject.mesh | Leukocytes | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Microscopy, Fluorescence | |
dc.subject.mesh | Hematology | |
dc.subject.mesh | Nanotechnology | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Microscopy, Fluorescence | |
dc.subject.mesh | Erythrocytes | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Blood Platelets | |
dc.subject.mesh | Blood Cells | |
dc.subject.mesh | Hematology | |
dc.subject.mesh | Nanotechnology | |
dc.subject.mesh | Leukocytes | |
dc.title | Nanoscale insights into hematology: super-resolved imaging on blood cell structure, function, and pathology. | |
dc.type | Journal Article | |
utslib.citation.volume | 22 | |
utslib.location.activity | England | |
utslib.for | 10 Technology | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
utslib.copyright.status | open_access | * |
dc.rights.license | This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2024-08-01T04:42:06Z | |
pubs.issue | 1 | |
pubs.publication-status | Published online | |
pubs.volume | 22 | |
utslib.citation.issue | 1 |
Abstract:
Fluorescence nanoscopy, also known as super-resolution microscopy, has transcended the conventional resolution barriers and enabled visualization of biological samples at nanometric resolutions. A series of super-resolution techniques have been developed and applied to investigate the molecular distribution, organization, and interactions in blood cells, as well as the underlying mechanisms of blood-cell-associated diseases. In this review, we provide an overview of various fluorescence nanoscopy technologies, outlining their current development stage and the challenges they are facing in terms of functionality and practicality. We specifically explore how these innovations have propelled forward the analysis of thrombocytes (platelets), erythrocytes (red blood cells) and leukocytes (white blood cells), shedding light on the nanoscale arrangement of subcellular components and molecular interactions. We spotlight novel biomarkers uncovered by fluorescence nanoscopy for disease diagnosis, such as thrombocytopathies, malignancies, and infectious diseases. Furthermore, we discuss the technological hurdles and chart out prospective avenues for future research directions. This review aims to underscore the significant contributions of fluorescence nanoscopy to the field of blood cell analysis and disease diagnosis, poised to revolutionize our approach to exploring, understanding, and managing disease at the molecular level.
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