Fracture behaviors of ceramic tissue scaffolds for load bearing applications.

Entezari, A; Roohani-Esfahani, S-I; Zhang, Z; Zreiqat, H; Dunstan, CR; Li, Q

Fracture behaviors of ceramic tissue scaffolds for load bearing applications.

Entezari, A

Roohani-Esfahani, S-I Zhang, Z Zreiqat, H Dunstan, CR Li, Q

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Publisher:: NATURE PORTFOLIO
Publication Type:: Journal Article
Citation:: Sci Rep, 2016, 6, (1), pp. 28816
Issue Date:: 2016-07-12

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Field	Value	Language
dc.contributor.author	Entezari, A https://orcid.org/0000-0003-0504-8364
dc.contributor.author	Roohani-Esfahani, S-I
dc.contributor.author	Zhang, Z
dc.contributor.author	Zreiqat, H
dc.contributor.author	Dunstan, CR
dc.contributor.author	Li, Q
dc.date.accessioned	2024-09-04T01:30:44Z
dc.date.available	2016-06-08
dc.date.available	2024-09-04T01:30:44Z
dc.date.issued	2016-07-12
dc.identifier.citation	Sci Rep, 2016, 6, (1), pp. 28816
dc.identifier.issn	2045-2322
dc.identifier.issn	2045-2322
dc.identifier.uri	http://hdl.handle.net/10453/180609
dc.description.abstract	Healing large bone defects, especially in weight-bearing locations, remains a challenge using available synthetic ceramic scaffolds. Manufactured as a scaffold using 3D printing technology, Sr-HT-Gahnite at high porosity (66%) had demonstrated significantly improved compressive strength (53 ± 9 MPa) and toughness. Nevertheless, the main concern of ceramic scaffolds in general remains to be their inherent brittleness and low fracture strength in load bearing applications. Therefore, it is crucial to establish a robust numerical framework for predicting fracture strengths of such scaffolds. Since crack initiation and propagation plays a critical role on the fracture strength of ceramic structures, we employed extended finite element method (XFEM) to predict fracture behaviors of Sr-HT-Gahnite scaffolds. The correlation between experimental and numerical results proved the superiority of XFEM for quantifying fracture strength of scaffolds over conventional FEM. In addition to computer aided design (CAD) based modeling analyses, XFEM was conducted on micro-computed tomography (μCT) based models for fabricated scaffolds, which took into account the geometric variations induced by the fabrication process. Fracture strengths and crack paths predicted by the μCT-based XFEM analyses correlated well with relevant experimental results. The study provided an effective means for the prediction of fracture strength of porous ceramic structures, thereby facilitating design optimization of scaffolds.
dc.format	Electronic
dc.language	eng
dc.publisher	NATURE PORTFOLIO
dc.relation.ispartof	Sci Rep
dc.relation.isbasedon	10.1038/srep28816
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Bone Regeneration
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Ceramics
dc.subject.mesh	Compressive Strength
dc.subject.mesh	Computer-Aided Design
dc.subject.mesh	Finite Element Analysis
dc.subject.mesh	Fractures, Bone
dc.subject.mesh	Humans
dc.subject.mesh	Materials Testing
dc.subject.mesh	Porosity
dc.subject.mesh	Pressure
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Stress, Mechanical
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Weight-Bearing
dc.subject.mesh	X-Ray Microtomography
dc.subject.mesh	Humans
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Ceramics
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Materials Testing
dc.subject.mesh	Bone Regeneration
dc.subject.mesh	Finite Element Analysis
dc.subject.mesh	Compressive Strength
dc.subject.mesh	Stress, Mechanical
dc.subject.mesh	Weight-Bearing
dc.subject.mesh	Porosity
dc.subject.mesh	Pressure
dc.subject.mesh	Computer-Aided Design
dc.subject.mesh	Fractures, Bone
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	X-Ray Microtomography
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Bone Regeneration
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Ceramics
dc.subject.mesh	Compressive Strength
dc.subject.mesh	Computer-Aided Design
dc.subject.mesh	Finite Element Analysis
dc.subject.mesh	Fractures, Bone
dc.subject.mesh	Humans
dc.subject.mesh	Materials Testing
dc.subject.mesh	Porosity
dc.subject.mesh	Pressure
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Stress, Mechanical
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Weight-Bearing
dc.subject.mesh	X-Ray Microtomography
dc.title	Fracture behaviors of ceramic tissue scaffolds for load bearing applications.
dc.type	Journal Article
utslib.citation.volume	6
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-09-04T01:30:39Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	6
utslib.citation.issue	1

Abstract:

Healing large bone defects, especially in weight-bearing locations, remains a challenge using available synthetic ceramic scaffolds. Manufactured as a scaffold using 3D printing technology, Sr-HT-Gahnite at high porosity (66%) had demonstrated significantly improved compressive strength (53 ± 9 MPa) and toughness. Nevertheless, the main concern of ceramic scaffolds in general remains to be their inherent brittleness and low fracture strength in load bearing applications. Therefore, it is crucial to establish a robust numerical framework for predicting fracture strengths of such scaffolds. Since crack initiation and propagation plays a critical role on the fracture strength of ceramic structures, we employed extended finite element method (XFEM) to predict fracture behaviors of Sr-HT-Gahnite scaffolds. The correlation between experimental and numerical results proved the superiority of XFEM for quantifying fracture strength of scaffolds over conventional FEM. In addition to computer aided design (CAD) based modeling analyses, XFEM was conducted on micro-computed tomography (μCT) based models for fabricated scaffolds, which took into account the geometric variations induced by the fabrication process. Fracture strengths and crack paths predicted by the μCT-based XFEM analyses correlated well with relevant experimental results. The study provided an effective means for the prediction of fracture strength of porous ceramic structures, thereby facilitating design optimization of scaffolds.

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http://hdl.handle.net/10453/180609