Design and Fabrication of 3D printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defects.

Roohani-Esfahani, S-I; Newman, P; Zreiqat, H

Design and Fabrication of 3D printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defects.

Roohani-Esfahani, S-I Newman, P Zreiqat, H

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Publisher:: NATURE PORTFOLIO
Publication Type:: Journal Article
Citation:: Sci Rep, 2016, 6, (1), pp. 19468
Issue Date:: 2016-01-19

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Field	Value	Language
dc.contributor.author	Roohani-Esfahani, S-I
dc.contributor.author	Newman, P
dc.contributor.author	Zreiqat, H
dc.date.accessioned	2025-01-15T20:44:18Z
dc.date.available	2015-10-19
dc.date.available	2025-01-15T20:44:18Z
dc.date.issued	2016-01-19
dc.identifier.citation	Sci Rep, 2016, 6, (1), pp. 19468
dc.identifier.issn	2045-2322
dc.identifier.issn	2045-2322
dc.identifier.uri	http://hdl.handle.net/10453/183678
dc.description.abstract	A challenge in regenerating large bone defects under load is to create scaffolds with large and interconnected pores while providing a compressive strength comparable to cortical bone (100-150 MPa). Here we design a novel hexagonal architecture for a glass-ceramic scaffold to fabricate an anisotropic, highly porous three dimensional scaffolds with a compressive strength of 110 MPa. Scaffolds with hexagonal design demonstrated a high fatigue resistance (1,000,000 cycles at 1-10 MPa compressive cyclic load), failure reliability and flexural strength (30 MPa) compared with those for conventional architecture. The obtained strength is 150 times greater than values reported for polymeric and composite scaffolds and 5 times greater than reported values for ceramic and glass scaffolds at similar porosity. These scaffolds open avenues for treatment of load bearing bone defects in orthopaedic, dental and maxillofacial applications.
dc.format	Electronic
dc.language	eng
dc.publisher	NATURE PORTFOLIO
dc.relation.ispartof	Sci Rep
dc.relation.isbasedon	10.1038/srep19468
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Bone Regeneration
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Ceramics
dc.subject.mesh	Compressive Strength
dc.subject.mesh	Cortical Bone
dc.subject.mesh	Glass
dc.subject.mesh	Materials Testing
dc.subject.mesh	Polymers
dc.subject.mesh	Porosity
dc.subject.mesh	Printing
dc.subject.mesh	Reproducibility of Results
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Wound Healing
dc.subject.mesh	Polymers
dc.subject.mesh	Glass
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Ceramics
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Reproducibility of Results
dc.subject.mesh	Materials Testing
dc.subject.mesh	Bone Regeneration
dc.subject.mesh	Wound Healing
dc.subject.mesh	Compressive Strength
dc.subject.mesh	Porosity
dc.subject.mesh	Printing
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Cortical Bone
dc.subject.mesh	Bone Regeneration
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Ceramics
dc.subject.mesh	Compressive Strength
dc.subject.mesh	Cortical Bone
dc.subject.mesh	Glass
dc.subject.mesh	Materials Testing
dc.subject.mesh	Polymers
dc.subject.mesh	Porosity
dc.subject.mesh	Printing
dc.subject.mesh	Reproducibility of Results
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Wound Healing
dc.title	Design and Fabrication of 3D printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defects.
dc.type	Journal Article
utslib.citation.volume	6
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2025-01-15T20:44:17Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	6
utslib.citation.issue	1

Abstract:

A challenge in regenerating large bone defects under load is to create scaffolds with large and interconnected pores while providing a compressive strength comparable to cortical bone (100-150 MPa). Here we design a novel hexagonal architecture for a glass-ceramic scaffold to fabricate an anisotropic, highly porous three dimensional scaffolds with a compressive strength of 110 MPa. Scaffolds with hexagonal design demonstrated a high fatigue resistance (1,000,000 cycles at 1-10 MPa compressive cyclic load), failure reliability and flexural strength (30 MPa) compared with those for conventional architecture. The obtained strength is 150 times greater than values reported for polymeric and composite scaffolds and 5 times greater than reported values for ceramic and glass scaffolds at similar porosity. These scaffolds open avenues for treatment of load bearing bone defects in orthopaedic, dental and maxillofacial applications.

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http://hdl.handle.net/10453/183678