Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma.

Zhang, D; Tian, S; Liu, Y; Zheng, M; Yang, X; Zou, Y; Shi, B; Luo, L

Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma.

Zhang, D Tian, S Liu, Y Zheng, M Yang, X Zou, Y Shi, B

Luo, L

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Publisher:: NATURE PORTFOLIO
Publication Type:: Journal Article
Citation:: Nat Commun, 2022, 13, (1), pp. 6835
Issue Date:: 2022-11-11

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Field	Value	Language
dc.contributor.author	Zhang, D
dc.contributor.author	Tian, S
dc.contributor.author	Liu, Y
dc.contributor.author	Zheng, M
dc.contributor.author	Yang, X
dc.contributor.author	Zou, Y
dc.contributor.author	Shi, B https://orcid.org/0000-0002-1043-3163
dc.contributor.author	Luo, L
dc.date.accessioned	2025-01-28T06:54:48Z
dc.date.available	2022-10-26
dc.date.available	2025-01-28T06:54:48Z
dc.date.issued	2022-11-11
dc.identifier.citation	Nat Commun, 2022, 13, (1), pp. 6835
dc.identifier.issn	2041-1723
dc.identifier.issn	2041-1723
dc.identifier.uri	http://hdl.handle.net/10453/184434
dc.description.abstract	Glioblastoma multiforme (GBM) is one of the most fatal malignancies due to the existence of blood-brain barrier (BBB) and the difficulty to maintain an effective drug accumulation in deep GBM lesions. Here we present a biomimetic nanogel system that can be precisely activated by near infrared (NIR) irradiation to achieve BBB crossing and deep tumor penetration of drugs. Synthesized by crosslinking pullulan and poly(deca-4,6-diynedioic acid) (PDDA) and loaded with temozolomide and indocyanine green (ICG), the nanogels are inert to endogenous oxidative conditions but can be selectively disintegrated by ICG-generated reactive oxygen species upon NIR irradiation. Camouflaging the nanogels with apolipoprotein E peptide-decorated erythrocyte membrane further allows prolonged blood circulation and active tumor targeting. The precisely controlled NIR irradiation on tumor lesions excites ICG and deforms the cumulated nanogels to trigger burst drug release for facilitated BBB permeation and infiltration into distal tumor cells. These NIR-activatable biomimetic nanogels suppress the tumor growth in orthotopic GBM and GBM stem cells-bearing mouse models with significantly extended survival.
dc.format	Electronic
dc.language	eng
dc.publisher	NATURE PORTFOLIO
dc.relation.ispartof	Nat Commun
dc.relation.isbasedon	10.1038/s41467-022-34462-8
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Mice
dc.subject.mesh	Animals
dc.subject.mesh	Glioblastoma
dc.subject.mesh	Nanogels
dc.subject.mesh	Biomimetics
dc.subject.mesh	Temozolomide
dc.subject.mesh	Indocyanine Green
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Glioblastoma
dc.subject.mesh	Indocyanine Green
dc.subject.mesh	Biomimetics
dc.subject.mesh	Temozolomide
dc.subject.mesh	Nanogels
dc.subject.mesh	Mice
dc.subject.mesh	Animals
dc.subject.mesh	Glioblastoma
dc.subject.mesh	Nanogels
dc.subject.mesh	Biomimetics
dc.subject.mesh	Temozolomide
dc.subject.mesh	Indocyanine Green
dc.subject.mesh	Cell Line, Tumor
dc.title	Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2025-01-28T06:54:45Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	13
utslib.citation.issue	1

Abstract:

Glioblastoma multiforme (GBM) is one of the most fatal malignancies due to the existence of blood-brain barrier (BBB) and the difficulty to maintain an effective drug accumulation in deep GBM lesions. Here we present a biomimetic nanogel system that can be precisely activated by near infrared (NIR) irradiation to achieve BBB crossing and deep tumor penetration of drugs. Synthesized by crosslinking pullulan and poly(deca-4,6-diynedioic acid) (PDDA) and loaded with temozolomide and indocyanine green (ICG), the nanogels are inert to endogenous oxidative conditions but can be selectively disintegrated by ICG-generated reactive oxygen species upon NIR irradiation. Camouflaging the nanogels with apolipoprotein E peptide-decorated erythrocyte membrane further allows prolonged blood circulation and active tumor targeting. The precisely controlled NIR irradiation on tumor lesions excites ICG and deforms the cumulated nanogels to trigger burst drug release for facilitated BBB permeation and infiltration into distal tumor cells. These NIR-activatable biomimetic nanogels suppress the tumor growth in orthotopic GBM and GBM stem cells-bearing mouse models with significantly extended survival.

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http://hdl.handle.net/10453/184434