Neural cell responses to wear debris from spinal instrumentation and devices

Wen, David Jiawei

Neural cell responses to wear debris from spinal instrumentation and devices

Wen, David Jiawei

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Publication Type:: Thesis
Issue Date:: 2024

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Field	Value	Language
dc.contributor.author	Wen, David Jiawei
dc.date.accessioned	2025-04-11T00:51:12Z
dc.date.available	2025-04-11T00:51:12Z
dc.date.issued	2024
dc.identifier.uri	http://hdl.handle.net/10453/186825
dc.description	University of Technology Sydney. Faculty of Engineering and Information Technology.	en_US.UTF-8
dc.description.abstract	Back pain is now the leading cause of disability worldwide and affects approximately 619 million people globally. The prevalence of spinal surgery involving the implantation of spinal implants and/or instrumentation continues to increase due to advancements in medical technologies and increased incidence of spine-related degenerative conditions. Despite the successes and increased use of spinal surgery for patients with back pain, the longevity of spinal implants may be compromised by issues including mechanical challenges and biological factors. One of the mechanical problems causing spinal implant failures is the generation of wear debris resulting in adverse biological responses including inflammation and osteolysis. In addition, the proximity of neural tissues and cells of the central nervous system poses a challenge as the tissues and cells may be damaged if exposed to wear debris. By understanding how neural cells respond to wear debris from spinal devices, researchers and clinicians can improve outcomes of spinal surgeries and support the development of more spinal implants that improve patient quality of life. In the current study, a novel 3D bioprinted model was developed to investigate the neural cell responses to different wear particles from different biomaterials.	en_US.UTF-8
dc.format	Thesis (PhD)
dc.language.iso	en_US	en_US.UTF-8
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/186825/1/thesis.pdf
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	© 2024 David Jiawei Wen
dc.rights	au.edu.uts.lib/cph
dc.title	Neural cell responses to wear debris from spinal instrumentation and devices	en_US.UTF-8
dc.type	Thesis
utslib.copyright.status	open_access	*

Abstract:

Back pain is now the leading cause of disability worldwide and affects approximately 619 million people globally. The prevalence of spinal surgery involving the implantation of spinal implants and/or instrumentation continues to increase due to advancements in medical technologies and increased incidence of spine-related degenerative conditions. Despite the successes and increased use of spinal surgery for patients with back pain, the longevity of spinal implants may be compromised by issues including mechanical challenges and biological factors. One of the mechanical problems causing spinal implant failures is the generation of wear debris resulting in adverse biological responses including inflammation and osteolysis. In addition, the proximity of neural tissues and cells of the central nervous system poses a challenge as the tissues and cells may be damaged if exposed to wear debris. By understanding how neural cells respond to wear debris from spinal devices, researchers and clinicians can improve outcomes of spinal surgeries and support the development of more spinal implants that improve patient quality of life. In the current study, a novel 3D bioprinted model was developed to investigate the neural cell responses to different wear particles from different biomaterials.

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http://hdl.handle.net/10453/186825