Computational design in digital and bio fabrication

Bahrami, Hassan

Computational design in digital and bio fabrication

Bahrami, Hassan

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Publication Type:: Thesis
Issue Date:: 2024

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Field	Value	Language
dc.contributor.author	Bahrami, Hassan
dc.date.accessioned	2025-05-13T04:30:01Z
dc.date.available	2025-05-13T04:30:01Z
dc.date.issued	2024
dc.identifier.uri	http://hdl.handle.net/10453/187343
dc.description	University of Technology Sydney. Faculty of Engineering and Information Technology.	en_US.UTF-8
dc.description.abstract	Computational design holds promising applications in digital fabrication and biofabrication, offering innovative solutions to complex challenges in manufacturing and tissue engineering. In this thesis, we explore the application of computational design principles in these domains and present novel approaches to address two specific problems. In the realm of biofabrication, we introduce a physically-based simulation framework for the elastic-plastic fusion of 3D bioprinted spheroids. Spheroids are microtissues containing cells organized in a spherical shape that are used in biofabrication to create human tissue. Specifically, we employ bioprinting spheroids to fabricate heart tissues in our lab. However, achieving tissue with the desired geometrical shape requires understanding how they fuse after printing. Therefore, we have developed a physically-based simulation framework based on elastic-plastic solid and fluid continuum mechanics models using the smoothed particle hydrodynamics (SPH) method. This accurately captures the fusion process of spheroids and facilitates reverse engineering to achieve tissue with the desired shape. Our method can save significant time and costs compared to trial-and-error methods. Through extensive sensitivity and morphological analyses, we validate our simulations against in-vitro experiments, demonstrating their capability to predict and control tissue geometries. Shifting our focus to digital fabrication, we introduce the concept of "Ruling Patches," a method that approximates triangular meshes with developable patches driven by surface line features. Developable shapes find practical application in manufacturing, where surfaces of three-dimensional shapes can be efficiently constructed from flat patches. We demonstrate the effectiveness of our method in achieving aesthetic and manufacturable patch layouts, showcasing its superiority over existing techniques. Our work advances the understanding of complex phenomena in digital and biofabrication and opens new avenues for research and development in these fields. By providing efficient computational tools and frameworks, our contributions empower researchers and practitioners to tackle emerging challenges and drive innovation in manufacturing and tissue engineering.	en_US.UTF-8
dc.format	Thesis (PhD)
dc.language.iso	en_US	en_US.UTF-8
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/187343/1/thesis.pdf
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	© 2024 Hassan Bahrami
dc.rights	au.edu.uts.lib/cph
dc.title	Computational design in digital and bio fabrication	en_US.UTF-8
dc.type	Thesis
utslib.copyright.status	open_access	*

Abstract:

Computational design holds promising applications in digital fabrication and biofabrication, offering innovative solutions to complex challenges in manufacturing and tissue engineering. In this thesis, we explore the application of computational design principles in these domains and present novel approaches to address two specific problems. In the realm of biofabrication, we introduce a physically-based simulation framework for the elastic-plastic fusion of 3D bioprinted spheroids. Spheroids are microtissues containing cells organized in a spherical shape that are used in biofabrication to create human tissue. Specifically, we employ bioprinting spheroids to fabricate heart tissues in our lab. However, achieving tissue with the desired geometrical shape requires understanding how they fuse after printing. Therefore, we have developed a physically-based simulation framework based on elastic-plastic solid and fluid continuum mechanics models using the smoothed particle hydrodynamics (SPH) method. This accurately captures the fusion process of spheroids and facilitates reverse engineering to achieve tissue with the desired shape. Our method can save significant time and costs compared to trial-and-error methods. Through extensive sensitivity and morphological analyses, we validate our simulations against in-vitro experiments, demonstrating their capability to predict and control tissue geometries. Shifting our focus to digital fabrication, we introduce the concept of "Ruling Patches," a method that approximates triangular meshes with developable patches driven by surface line features. Developable shapes find practical application in manufacturing, where surfaces of three-dimensional shapes can be efficiently constructed from flat patches. We demonstrate the effectiveness of our method in achieving aesthetic and manufacturable patch layouts, showcasing its superiority over existing techniques. Our work advances the understanding of complex phenomena in digital and biofabrication and opens new avenues for research and development in these fields. By providing efficient computational tools and frameworks, our contributions empower researchers and practitioners to tackle emerging challenges and drive innovation in manufacturing and tissue engineering.

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http://hdl.handle.net/10453/187343