Nanocarrier-Based Systems for Targeted Delivery: Current Challenges and Future Directions.

Xu, Z; Xie, Y; Chen, W; Deng, W

Nanocarrier-Based Systems for Targeted Delivery: Current Challenges and Future Directions.

Xu, Z Xie, Y Chen, W Deng, W

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: MedComm (2020), 2025, 6, (9), pp. e70337
Issue Date:: 2025-09

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Field	Value	Language
dc.contributor.author	Xu, Z
dc.contributor.author	Xie, Y
dc.contributor.author	Chen, W
dc.contributor.author	Deng, W https://orcid.org/0000-0002-9413-0978
dc.date.accessioned	2025-09-03T07:58:56Z
dc.date.available	2025-07-21
dc.date.available	2025-09-03T07:58:56Z
dc.date.issued	2025-09
dc.identifier.citation	MedComm (2020), 2025, 6, (9), pp. e70337
dc.identifier.issn	2688-2663
dc.identifier.issn	2688-2663
dc.identifier.uri	http://hdl.handle.net/10453/189627
dc.description.abstract	Nanomaterials have become promising platforms in the field of drug and gene delivery, offering unique advantages over traditional therapeutic approaches. Their tunable physicochemical properties enable improved pharmacokinetics and therapeutic performance. A wide range of nanocarriers, including lipid-based, polymer-based, and hybrid systems, have been rapidly developed and are attracting increasing attention in both preclinical and clinical research. However, despite promising preclinical outcomes, these systems still encounter critical challenges in achieving precise delivery to specific tissues, cells, and intracellular compartments. This review provides a comprehensive assessment of recent advances in the design and application of nanocarriers for targeted delivery, with emphasis on strategies designed for nuclear targeting. In the context of nuclear targeting, it explores passive approaches involving modulation of particle size, morphology, and surface charge, alongside active targeting strategies incorporating nuclear localization signals and other ligands. In addition to highlighting progress, the review examines the limitations associated with delivery efficiency, off-target effects, and barriers to clinical translation. By addressing both advances and ongoing challenges, this review provides valuable insights into the design and engineering of targeted nanocarriers. These developments are crucial for unlocking the full potential of precision nanomedicine.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	WILEY
dc.relation.ispartof	MedComm (2020)
dc.relation.isbasedon	10.1002/mco2.70337
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Nanocarrier-Based Systems for Targeted Delivery: Current Challenges and Future Directions.
dc.type	Journal Article
utslib.citation.volume	6
utslib.location.activity	China
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2025-09-03T07:58:54Z
pubs.issue	9
pubs.publication-status	Published online
pubs.volume	6
utslib.citation.issue	9

Abstract:

Nanomaterials have become promising platforms in the field of drug and gene delivery, offering unique advantages over traditional therapeutic approaches. Their tunable physicochemical properties enable improved pharmacokinetics and therapeutic performance. A wide range of nanocarriers, including lipid-based, polymer-based, and hybrid systems, have been rapidly developed and are attracting increasing attention in both preclinical and clinical research. However, despite promising preclinical outcomes, these systems still encounter critical challenges in achieving precise delivery to specific tissues, cells, and intracellular compartments. This review provides a comprehensive assessment of recent advances in the design and application of nanocarriers for targeted delivery, with emphasis on strategies designed for nuclear targeting. In the context of nuclear targeting, it explores passive approaches involving modulation of particle size, morphology, and surface charge, alongside active targeting strategies incorporating nuclear localization signals and other ligands. In addition to highlighting progress, the review examines the limitations associated with delivery efficiency, off-target effects, and barriers to clinical translation. By addressing both advances and ongoing challenges, this review provides valuable insights into the design and engineering of targeted nanocarriers. These developments are crucial for unlocking the full potential of precision nanomedicine.

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http://hdl.handle.net/10453/189627