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Erlotinib is a reversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that acts by inhibiting signaling pathways, resulting in the disruption of cancerous cell proliferation. ...
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CONTEXT: Carriers of germline pathogenic variants (PVs) in succinate dehydrogenase type B (SDHB) are at increased risk of developing pheochromocytomas and paragangliomas (PPGLs). Understanding thei...
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Wigg, A
Tibballs, J
Woodman, R
Stuart, K
Le, H
Roberts, SK
Olynyk, JK
Strasser, SI
Wallace, M
Martin, J
Haworth, A
Hardcastle, N
Loo, KF
Tang, C
Lee, YY
Chu, J
De Abreu Lourenco, R
Koukourou, A
De Boo, D
McLean, K
Buck, J
Sawhney, R
Nicoll, A
Dev, A
Wood, M
Braund, A
Weltman, M
Khor, R
Levy, M
Wang, T
Potter, M
Haridy, J
Raj, A
Duncan, O
Zekry, A
Collier, N
O'Beirne, J
Holliday, C
Trada, Y
Tronidjaja, J
George, J
Pryor, D
BACKGROUND: Therapeutic options for early-stage hepatocellular carcinoma (HCC) in individual patients can be limited by tumor and location, liver dysfunction and comorbidities. Many patients with e...
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Abstract
Background
Malaria vaccine is one of the critical areas in tropic...
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Loughnan, SA
Lancaster, A
Crocker, S
Astell, C
Griffin, A
Wojcieszek, AM
Boyle, FM
Ellwood, D
Dean, J
Horey, D
Callander, E
Jackson, C
Seeho, S
Shand, A
Flenady, V
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BACKGROUND: The principal route of HIV infection in children is vertical transmission. Thus, this study aimed to assess the incidence of mother-to-child transmission of HIV and predictors of positi...
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Gofton, C
Di Bartolomeo, A
Boutros, R
Zurynski, YA
Stafford-Bell, F
Caldwell, K
McCaughan, G
Zekry, A
Strasser, SI
Levy, M
Sheehan, C
Goodall, S
Davis, JM
Sheahan, L
Liu, K
Greenaway, S
Davison, S
Du Huynh, T
Quadri, Z
Agar, M
George, J
BACKGROUND: Integration of symptom and palliative care for people with advanced cancer is established in many tumour types, but its role in people with hepatocellular carcinoma (HCC) has not been c...
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Vasilescu, SA
Goss, DM
Gurner, KH
Kelley, RL
Mazi, M
De Bond, FK
Lorimer, J
Horta, F
Parast, FY
Gardner, DK
Nosrati, R
Warkiani, ME
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This paper considers the development and evolution of the short-form 6 dimensions (SF-6D), a generic preference-weighted measure consisting of a health classification with accompanying value set th...
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BACKGROUND: Supporting clinical teams to improve care for inpatients with palliative care needs and their carers is a known priority. Patient reported experience measures (PREMs) may assist in impr...
